Direct Oral Anticoagulant Reversal in the Pediatric Emergency Department

Autor:	Jessica, Otero, Suzan S, Mazor, James, Leoni
Rok vydání:	2022
Předmět:	Adult Pediatrics Perinatology and Child Health Emergency Medicine Humans Administration Oral Anticoagulants Warfarin General Medicine Child Emergency Service Hospital Anticoagulation Reversal
Zdroj:	Pediatric Emergency Care. 38:621-625
ISSN:	1535-1815 0749-5161
Popis:	Direct oral anticoagulants have been used in the adult population for years and are being used more frequently in pediatrics. Direct oral anticoagulants are chosen preferentially because they do not require close outpatient monitoring, have an equal or better safety profile, and are easy for patients to take. Warfarin is the previous, more commonly used oral anticoagulant and acts as a vitamin K antagonist. Direct oral anticoagulants mechanism of action is different in that they directly inhibit part of the coagulation cascade accomplishing the same end goal. Given their differing mechanisms, they require alternate medications for proper reversal when concerned about overdose of life-threatening bleeds. This review will outline the most commonly used direct oral anticoagulants in pediatric populations and the supporting (mainly adult) data available for proper reversal of these medications in times of need.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95deb476e25534a4c948ea4e4f33dff9 https://doi.org/10.1097/pec.0000000000002847 Zobrazit plný text záznamu