Pharmacological Properties of SD-282 – An α-Isoform Selective Inhibitor for p38 MAP Kinase
| Autor: | Gregory R. Luedtke, Yuanying Anne Huang, Sundeep Dugar, Jose Carlos Chavez, Ramona Almirez, Sarvajit Chakravarty, Cheng Ping Mao, Ann M. Kapoun, Satyanarayana Medicherla, Gladys T. Muiru, Linda S. Higgins, Aaron N. Nguyen, Don Lim, Yu-Wang Liu, Heather K. Webb, Bruce Koppelman, Babu J. Mavunkel, Ying Feng, Andrew A. Protter |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Indoles Ovalbumin medicine.medical_treatment Guinea Pigs Anti-Inflammatory Agents Arthritis Inflammation Context (language use) In Vitro Techniques Pharmacology p38 Mitogen-Activated Protein Kinases Mice In vivo Sepsis medicine Animals Humans Enzyme Inhibitors Lung Mice Inbred BALB C biology Tumor Necrosis Factor-alpha business.industry Biological activity General Medicine medicine.disease Disease Models Animal Cytokine Mitogen-activated protein kinase Immunology biology.protein Female Tumor necrosis factor alpha medicine.symptom business Granulocytes |
| Zdroj: | Pharmacology. 81:204-220 |
| ISSN: | 1423-0313 0031-7012 |
| Popis: | The effects of small-molecule p38 inhibitors in numerous models of different disease states have been published, including those of SD-282, an indole-5-carboxamide inhibitor. The aim of the present study was to evaluate the pharmacological activity of SD-282 on cytokine production in vitro as well as in 2 in vivo models of inflammation in order to illuminate the role of this particular inhibitor in diverse disease states. The results presented here provide further characterization of SD-282 and provide a context in which to interpret the activity of this p38 inhibitor in models of arthritis, pain, myocardial injury, sepsis and asthma; all of which have an inflammatory component. SD-282 represents a valuable tool to elucidate the role of p38 MAP kinase in multiple models of inflammation. |
| Databáze: | OpenAIRE |
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