Vitamin D deficiency in adult patients with ulcerative colitis: Prevalence and relationship with disease severity, extent, and duration
| Autor: | Kartar Singh, Rakesh Kochhar, Chetana Vaishnavi, Talha Noor, Arjun Datt Law, Usha Dutta, Sanjay Kumar Bhadada, Shiva Kumar |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Vitamin Pancolitis medicine.medical_specialty Time Factors Comorbidity Disease Severity of Illness Index Inflammatory bowel disease Gastroenterology vitamin D deficiency Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Prevalence medicine Vitamin D and neurology Animals Humans Cholecalciferol business.industry Middle Aged Hepatology Vitamin D Deficiency medicine.disease Ulcerative colitis chemistry 030220 oncology & carcinogenesis Colitis Ulcerative Female 030211 gastroenterology & hepatology medicine.symptom business |
| Zdroj: | Indian Journal of Gastroenterology. 38:6-14 |
| ISSN: | 0975-0711 0254-8860 |
| DOI: | 10.1007/s12664-019-00932-z |
| Popis: | Vitamin D plays a key role in gut immunity and maintenance of the mucosal barrier. Vitamin D deficiency (VDD) worsens ulcerative colitis (UC) and its supplementation ameliorates the disease in mouse models. The prevalence and predictors of VDD in UC are not known.Consecutive patients with UC (n = 80) underwent clinical, endoscopic, and histological evaluation to assess the extent, severity using UC disease activity index (UCDAI) score, and duration of illness. An equal number of age and gender-matched healthy adults without any features of inflammatory bowel disease (IBD) living in the same latitude were identified as controls. The serum 25-hydroxy vitamin DThe patients and controls were similar in age and gender (40 ± 11.4 years, 51% male vs. 40 ± 12 years, 51% male; p = 1.000). Median vitamin D levels among patients were lower than the controls (18.1 ng/mL [IQR 14] vs. 32.5 ng/mL [IQR 36]; p 0.001). Patients were more often VDD (56% vs. 40%) or insufficient (34% vs. 9%) and less often sufficient (9% vs. 40%) or optimal (1% vs. 11%), in contrast to controls (p 0.001). Median vitamin D levels were lower in those with UCDAI 6 (15 vs. 21 ng/mL; p = 0.01), having pancolitis (13 vs. 21 ng/mL, p = 0.01), and longer duration of illness 2 years (13.8 vs. 20.8; p = 0.025). Vitamin D levels showed a negative correlation with frequency of stools (rho = - 0.244, p = 0.05), disease duration (rho = - 0.244, p = 0.007) and UCDAI score (r = - 0.348, p = 0.002).VDD is highly prevalent among patients with UC. Patients with longer disease duration, more severe symptoms, and pancolitis are likely to have lower vitamin D levels. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink