Adiponectin levels decrease independently of body mass index and diabetes type after the normalization of hyperglycemia
| Autor: | Meltem Akkaş, Nese Cinar, Duygu Yazgan Aksoy, Okan Yildiz, Aydan Usman, Fatma Ucar, Nalan Metin Aksu |
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| Přispěvatelé: | MÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çınar, Neşe, Acibadem University Dspace |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty medicine.medical_treatment body mass index 030204 cardiovascular system & hematology Article Body Mass Index 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation Diabetes mellitus Internal medicine medicine Humans Insulin Adiponectin secretion Aged 0303 health sciences adiponectin Adiponectin 030306 microbiology business.industry Body Weight nutritional and metabolic diseases Hyperglycemia adiponectin body mass index General Medicine Emergency department Middle Aged medicine.disease Diabetes Mellitus Type 1 Endocrinology Diabetes Mellitus Type 2 Hyperglycemia Female Complication business Body mass index |
| Zdroj: | Turkish Journal of Medical Sciences Volume: 50, Issue: 2 312-315 |
| ISSN: | 1303-6165 1300-0144 |
| Popis: | WOS: 000525954500005 PubMed ID: 31905496 Background/aim: Acute hyperglycemia is generally a frequently encountered condition in the emergency department (ED), because it is seen as a complication of diabetes mellitus (DM). In this study, we aimed to detect the change in adiponectin levels during acute hyperglycemic states and after normalization of blood glucose with insulin treatment. Materials and methods: Forty-eight patients over the age of 18 years who were admitted to the ED with acute hyperglycemia were included in the study. Serum samples were taken from patients on admission and 6 h after the normalization of blood glucose with insulin treatment, and adiponectin levels were measured in both samples. Results: There were 21 female and 27 male patients with a median age of 58.7 +/- 18 years. All patients' blood glucose levels were normalized with insulin treatment according to international recommendations. Serum adiponectin levels decreased significantly after the normalization of blood glucose in the whole group. Adiponectin levels decreased from 28.9 +/- 16.5 to 12.1 +/- 10.9 mu g/mL (P < 0.0001) in the whole group. This decrease was independent of diabetes type and body mass index. Conclusion: Normalization of blood glucose in patients with hyperglycemia caused a decrease in adiponectin levels, independent of diabetes type and/or body weight in an acute emergency setting. Inhibited upregulation of adiponectin secretion and/or blunted suppressive effect of insulin due to hyperglycemia or exogenous insulin administration may have caused the decrease in adiponectin levels. Hacettepe University Scientific Research and Developmental OfficeHacettepe University [010D02101002] This work was supported by the Hacettepe University Scientific Research and Developmental Office (010D02101002). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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