Combined sterile insect technique and incompatible insect technique: The first proof-of-concept to suppress Aedes aegypti vector populations in semi-rural settings in Thailand

Autor: Wanitch Limohpasmanee, Suwannapa Ninphanomchai, Pattamaporn Kittayapong, Uruyakorn Chansang, Chitti Chansang, Piti Mongkalangoon
Rok vydání: 2018
Předmět:
0301 basic medicine
Male
Rural Population
Veterinary medicine
Viral Diseases
Mosquito Control
RC955-962
Population Dynamics
Insect
Disease Vectors
medicine.disease_cause
Mosquitoes
Dengue fever
Zika virus
Geographical Locations
Sterile insect technique
0302 clinical medicine
Aedes
Arctic medicine. Tropical medicine
Medicine and Health Sciences
Chikungunya
media_common
Sex Characteristics
biology
Eukaryota
Thailand
Insects
Infectious Diseases
Wolbachia
Female
Public aspects of medicine
RA1-1270
Research Article
Neglected Tropical Diseases
Asia
Arthropoda
Infectious Disease Control
media_common.quotation_subject
030231 tropical medicine
Aedes aegypti
Mosquito Vectors
Aedes Aegypti
03 medical and health sciences
medicine
Animals
Humans
Infertility
Male
Bacteria
Public Health
Environmental and Occupational Health
Organisms
Biology and Life Sciences
Chikungunya Infection
biology.organism_classification
medicine.disease
Tropical Diseases
Invertebrates
Insect Vectors
Species Interactions
030104 developmental biology
Vector (epidemiology)
People and Places
Entomology
Zdroj: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 13, Iss 10, p e0007771 (2019)
ISSN: 1935-2735
Popis: Background Important arboviral diseases, such as dengue, chikungunya, and Zika virus infections, are transmitted mainly by the Aedes aegypti vector. So far, controlling this vector species with current tools and strategies has not demonstrated sustainable and significant impacts. Our main objective was to evaluate whether open field release of sterile males, produced from combining the sterile insect technique using radiation with the insect incompatible technique through Wolbachia-induced incompatibility (SIT/IIT), could suppress natural populations of Ae. aegypti in semi-rural village settings in Thailand. Methodology/Principal findings Irradiated Wolbachia-infected Aedes aegypti males produced by the SIT/IIT approach were completely sterile and were able to compete with the wild fertile ones. Open field release of these sterile males was conducted in an ecologically isolated village in Chachoengsao Province, eastern Thailand. House-to-house visit and media reports resulted in community acceptance and public awareness of the technology. During intervention, approximately 100–200 sterile males were released weekly in each household. After 6 months of sterile male release, a significant reduction (p
Author summary Dengue, chikungunya, and Zika are important diseases that pass to humans only by the bites of Aedes aegypti mosquitoes infected with these viruses. Due to the lack of an effective vaccine and drug to cure these diseases, mosquito control is the only method available to reduce disease risk. Most of the available preventive and control measures involve an application of chemical-based products. The inappropriate use of chemicals causes insecticide resistance and environmental contamination. In this study, we report on the pilot trial of an alternative, safe, and environmental friendly approach to suppress Ae. aegypti mosquito populations. This alternative method involves the release of sterile Ae. aegypti males that were infected with, naturally-occurring, insect bacteria Wolbachia, and were irradiated at low doses to obtain full sterilization. The pilot trial involved the release of 100–200 sterile males per household in a treated area over a 6-month period. High efficacy of this approach was evidenced from a significant reduction in the numbers of wild Ae. aegypti females and an increase in sterility by reduction in the egg hatch rate of wild Ae. aegypti females in the treated area. Public awareness through media resulted in public support to conduct trials in wider areas.
Databáze: OpenAIRE
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