Synthetic Approaches toward Monocyclic 3‐Amino‐β‐lactams
| Autor: | Tuyen Van Nguyen, Matthias D'hooghe, Sari Deketelaere, Christian V. Stevens |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
cyclization
medicine.drug_class Stereochemistry Antibiotics Substituent Reviews SOLID-PHASE SYNTHESIS Review D-glyceraldehyde acetonide CHROMIUM CARBENE COMPLEXES 010402 general chemistry Ring (chemistry) 01 natural sciences D-GLYCERALDEHYDE ACETONIDE chemistry.chemical_compound Solid-phase synthesis ALDEHYDE-DERIVED IMINES β lactams medicine ASYMMETRIC-SYNTHESIS 3-amino-beta-lactams 3-amino-β-lactams Staudinger synthesis cycloaddition AMINO-BETA-LACTAMS HIGHLY STEREOSELECTIVE-SYNTHESIS ENOLATE-IMINE CONDENSATION 010405 organic chemistry Chemistry General Chemistry Combinatorial chemistry 0104 chemical sciences reactivity INTERCEDED DIASTEREOSELECTIVE SYNTHESIS SILYLATED KETENE ACETALS |
| Zdroj: | ChemistryOpen CHEMISTRYOPEN |
| ISSN: | 2191-1363 |
| Popis: | Due to the emerging resistance against classical beta-lactam-based antibiotics, a growing number of bacterial infections has become harder to treat. This alarming tendency necessitates continued research on novel antibacterial agents. Many classes of b- lactam antibiotics are characterized by the presence of the 3- aminoazetidin-2-one core, which resembles the natural substrate of the target penicillin-binding proteins. In that re-spect, this Review summarizes the different synthetic pathways toward this key structure for the development of new antibacterial agents. The most extensively applied methods for 3-amino-beta-lactam ring formation are discussed, in addition to a few less common strategies. Moreover, approaches to introduce the 3-amino substituent after ring formation are also covered. |
| Databáze: | OpenAIRE |
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