How strand exchange protein function benefits from ATP hydrolysis
| Autor: | Douglas K. Bishop, Diedre Reitz, Yuen-Ling Chan |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
1.1 Normal biological development and functioning
ATPase Biology Article Homology (biology) Motor protein chemistry.chemical_compound Adenosine Triphosphate Underpinning research ATP hydrolysis Genetics Cancer Adenosine Triphosphatases Protein function Hydrolysis DNA Rec A Recombinases chemistry Biochemistry biology.protein Generic health relevance Homologous recombination Recombination Biotechnology Developmental Biology |
| Zdroj: | Current opinion in genetics & development |
| ISSN: | 0959-437X |
| DOI: | 10.1016/j.gde.2021.06.016 |
| Popis: | Members of the RecA family of strand exchange proteins carry out the central reaction in homologous recombination. These proteins are DNA-dependent ATPases, although their ATPase activity is not required for the key functions of homology search and strand exchange. We review the literature on the role of the intrinsic ATPase activity of strand exchange proteins. We also discuss the role of ATP-hydrolysis-dependent motor proteins that serve as strand exchange accessory factors, with an emphasis on the eukaryotic Rad54 family of double strand DNA-specific translocases. The energy from ATP allows recombination events to progress from the strand exchange stage to subsequent stages. ATP hydrolysis also functions to corrects DNA binding errors, including particularly detrimental binding to double strand DNA. |
| Databáze: | OpenAIRE |
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