Geno- and Phenotypic Characterization of Human Cytomegalovirus Mutants Selected In Vitro after Letermovir (AIC246) Exposure
| Autor: | Holger Zimmermann, Christine Hempel, Helga Ruebsamen-Schaeff, Thomas Goldner, Peter Lischka |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Human cytomegalovirus
viruses Mutant Congenital cytomegalovirus infection Cytomegalovirus Drug resistance DNA-Directed DNA Polymerase Acetates Antiviral Agents Letermovir Drug Resistance Viral medicine Humans Pharmacology (medical) Mode of action Polymerase Pharmacology Genetics biology virus diseases medicine.disease Phenotype Virology Infectious Diseases biology.protein Quinazolines medicine.drug |
| Popis: | Letermovir is a novel antiviral compound currently in clinical development for the prevention of human cytomegalovirus (HCMV) infections. In contrast to all currently approved anti-HCMV drugs that target the viral DNA polymerase, letermovir acts via a distinct mode of action involving the viral terminase subunit pUL56. To extend our understanding of potential letermovir resistance mechanisms, we used marker transfer to characterize mutations identified in letermovir-resistant HCMV variants that were selected in cell culture. |
| Databáze: | OpenAIRE |
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