Tumor-associated macrophage heterogeneity is driven by tissue territories in breast cancer
| Autor: | Marie, Laviron, Maxime, Petit, Eléonore, Weber-Delacroix, Alexis J, Combes, Arjun Rao, Arkal, Sandrine, Barthélémy, Tristan, Courau, David A, Hume, Christophe, Combadière, Matthew F, Krummel, Alexandre, Boissonnas |
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| Přispěvatelé: | Centre d'Immunologie et des Maladies Infectieuses (CIMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), University of California [San Francisco] (UC San Francisco), University of California (UC), University of Queensland [Brisbane], Boissonnas, Alexandre, University of California [San Francisco] (UCSF), University of California |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
EXPRESSION
[SDV.BIO]Life Sciences [q-bio]/Biotechnology Breast Neoplasms [SDV.CAN]Life Sciences [q-bio]/Cancer PROGRESSION [SDV.BC]Life Sciences [q-bio]/Cellular Biology [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity DENDRITIC CELLS General Biochemistry Genetics and Molecular Biology Breast cancer SINGLE-CELL stomatognathic system [SDV.CAN] Life Sciences [q-bio]/Cancer RESIDENT MACROPHAGES MAMMARY-GLAND scRNA-seq REVEALS Medicine and Health Sciences Humans [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology skin and connective tissue diseases [SDV.IMM.II] Life Sciences [q-bio]/Immunology/Innate immunity spatial distribution tumor-associated macrophages ORIGIN Macrophages Biology and Life Sciences CP: Immunology scRNAseq ADIPOSE-TISSUE DIFFERENTIATION [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology [SDV.IMM.IA] Life Sciences [q-bio]/Immunology/Adaptive immunology Multiphoton imaging [SDV.IMM]Life Sciences [q-bio]/Immunology Female Transcriptome CP: Cancer hormones hormone substitutes and hormone antagonists |
| Zdroj: | CELL REPORTS Cell Reports Cell Reports, 2022, 39 (8), pp.110865. ⟨10.1016/j.celrep.2022.110865⟩ Cell Reports, Elsevier Inc, 2022, 39 (8), pp.110865. ⟨10.1016/j.celrep.2022.110865⟩ |
| ISSN: | 2211-1247 |
| DOI: | 10.1016/j.celrep.2022.110865⟩ |
| Popis: | International audience; Tissue-resident macrophages adapt to local signals within tissues to acquire specific functions. Neoplasia transforms the tissue, raising the question as to how the environmental perturbations contribute to tumor-associated macrophage (TAM) identity and functions. Combining single-cell RNA sequencing (scRNA-seq) with spatial localization of distinct TAM subsets by imaging, we discover that TAM transcriptomic programs follow two main differentiation paths according to their localization in the stroma or in the neoplastic epithelium of the mammary duct. Furthermore, this diversity is exclusively detected in a spontaneous tumor model and tracks the different tissue territories as well as the type of tumor lesion. These TAM subsets harbor distinct capacity to activate CD8+ T cells and phagocyte tumor cells, supporting that specific tumor regions, rather than defined activation states, are the major drivers of TAM plasticity and heterogeneity. The distinctions created here provide a framework to design cancer treatment targeting specific TAM niches. |
| Databáze: | OpenAIRE |
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