Role of parietal and principal gastric mucosa cells in the phenomenon of concentration of aluminum and indium
| Autor: | Ali El Hili, Henri-Noël Migeon, Aouatef Ben Ammar, Leila Tekaya, M. H. Jaafoura, Jean-Nicolas Audinot, Samira Maghraoui, Ahlem Ayadi |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Pathology medicine.medical_specialty Histology Spectrometry Mass Secondary Ion chemistry.chemical_element Indium Microanalysis Microscopy Electron Transmission Parietal Cells Gastric Intragastric administration medicine Gastric mucosa Animals Rats Wistar Aluminum Compounds Instrumentation Antrum Nitrates Chemistry digestive oral and skin physiology Rats Medical Laboratory Technology medicine.anatomical_structure Liver Gastric Mucosa Transmission electron microscopy Ultrastructure Biophysics Anatomy Lysosomes Electron Probe Microanalysis |
| Zdroj: | Microscopy Research and Technique. 75:182-188 |
| ISSN: | 1059-910X |
| DOI: | 10.1002/jemt.21041 |
| Popis: | The subcellular behavior of aluminum and indium, used in medical and industrial fields, was studied in the gastric mucosa and the liver after their intragastric administration to rats, using, two of the most sensitive methods of observation and microanalysis, the transmission electron microscopy, and the secondary ion mass spectrometry. The ultrastructural study showed the presence of electron dense deposits, in the lysosomes of parietal and principal gastric mucosa cells but no loaded lysosomes were observed in the different studied hepatic territories. The micro- analytical study allowed the identification of the chemical species present in those deposits as alu- minum or indium isotopes and the cartography of their distribution. No modification was observed in control rats tissues. In comparison to previous studies describing the mechanism of aluminum concentration in the gastric mucosa and showing that this element was concentrated in the lyso- somes of fundic and antral human gastric mucosa, our study provided additional informations about the types of cells involved in the phenomenon of concentration of aluminum and indium, which are the parietal and the principal cells of the gastric mucosa. Our study demonstrated that these cells have the ability to concentrate selectively aluminum and indium in their lysosomes, as a defensive reaction against intoxication by foreign elements. Microsc. Res. Tech. 75:182-188, 2012. V C 2011 Wiley Periodicals, Inc. |
| Databáze: | OpenAIRE |
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