The Role of Natural Products in Drug Discovery and Development against Neglected Tropical Diseases

Autor: Kelly Chibale, Peter Mubanga Cheuka, Godfrey Mayoka, Peggoty Mutai
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
congenital
hereditary
and neonatal diseases and abnormalities
Tuberculosis
natural products
human African trypanosomiasis
030231 tropical medicine
Antiprotozoal Agents
Pharmaceutical Science
Drug resistance
Review
Analytical Chemistry
lcsh:QD241-441
03 medical and health sciences
0302 clinical medicine
Elephantiasis
Filarial
lcsh:Organic chemistry
Environmental health
schistosomiasis
Drug Discovery
medicine
Humans
African trypanosomiasis
Physical and Theoretical Chemistry
Adverse effect
lymphatic filariasis
Leishmaniasis
Lymphatic filariasis
Biological Products
business.industry
Organic Chemistry
phytotherapy
Neglected Diseases
medicine.disease
Biotechnology
030104 developmental biology
Pharmaceutical care
Trypanosomiasis
African
Chemistry (miscellaneous)
Neglected tropical diseases
Molecular Medicine
Plant Preparations
business
Malaria
Zdroj: Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules, Vol 22, Iss 1, p 58 (2016)
ISSN: 1420-3049
Popis: Endemic in 149 tropical and subtropical countries, neglected tropical diseases (NTDs) affect more than 1 billion people annually, including 875 million children in developing economies. These diseases are also responsible for over 500,000 deaths per year and are characterized by long-term disability and severe pain. The impact of the combined NTDs closely rivals that of malaria and tuberculosis. Current treatment options are associated with various limitations including widespread drug resistance, severe adverse effects, lengthy treatment duration, unfavorable toxicity profiles, and complicated drug administration procedures. Natural products have been a valuable source of drug regimens that form the cornerstone of modern pharmaceutical care. In this review, we highlight the potential that remains untapped in natural products as drug leads for NTDs. We cover natural products from plant, marine, and microbial sources including natural-product-inspired semi-synthetic derivatives which have been evaluated against the various causative agents of NTDs. Our coverage is limited to four major NTDs which include human African trypanosomiasis (sleeping sickness), leishmaniasis, schistosomiasis and lymphatic filariasis.
Databáze: OpenAIRE
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