Large population study shows that adolescents with celiac disease have an increased risk of multiple autoimmune and nonautoimmune comorbidities
| Autor: | Dorit Tzur, Lior H. Katz, Amit Assa, Raanan Shamir, Yael Frenkel-Nir |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Population Arthritis Comorbidity Disease Autoimmune Diseases Cohort Studies 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Internal medicine medicine Humans 030212 general & internal medicine Israel education education.field_of_study business.industry Case-control study General Medicine Odds ratio medicine.disease Celiac Disease Case-Control Studies Pediatrics Perinatology and Child Health Female 030211 gastroenterology & hepatology business Cohort study |
| Zdroj: | Acta Paediatrica. 106:967-972 |
| ISSN: | 0803-5253 |
| Popis: | Aim Celiac disease (CD) is a systemic disorder that is associated with various autoimmune disorders and a higher prevalence of other diagnoses and complications. This large, cross-sectional, population-based study investigated the associations between CD and various medical conditions during late adolescence. Methods We included 2 001 353 Jewish Israeli adolescents who underwent a general health examination at a median age of 17.1 (16.9–17.4) years from 1988 to 2015. Comprehensive data regarding medical status were available for 1 588 041 (79%) subjects. A definite diagnosis of CD was based on accepted criteria. Covariate data included demographic measures and data on associated medical conditions. Results Overall, data on 7145 subjects with CD and 1 580 896 controls were analysed. Multivariate analyses showed that autoimmune diseases were significantly more common in subjects with CD, including insulin dependent diabetes, with an odds ratio (OR) of 5.5, inflammatory bowel diseases (OR = 3.8), arthritis (OR = 2.4), thyroid diseases (OR = 1.8) and psoriatic skin disorders (OR = 1.6). Further associations included asthma (OR = 1.5), bile stones (OR = 3.6), migraine (OR = 2.3), anaemia (OR = 1.7) and menstrual abnormalities (OR = 1.5). Long bone fractures and axial fractures were no more common in adolescents with CD than controls. Conclusion CD was already associated with multiple comorbidities by adolescence, and these were not limited to autoimmune disorders. |
| Databáze: | OpenAIRE |
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