Neuropeptide Y and Agouti-Related Peptide Mediate Complementary Functions of Hyperphagia and Reduced Energy Expenditure in Leptin Receptor Deficiency
Autor: | Shun Mei Liu, Streamson C. Chua, Genevieve Marcelin, Na Luo, Gary J. Schwartz |
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Rok vydání: | 2011 |
Předmět: |
Male
0301 basic medicine medicine.medical_specialty Adipose tissue Adipokine Neuropeptide 030209 endocrinology & metabolism Hyperphagia Peptide hormone Biology Mice 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine mental disorders medicine Animals Agouti-Related Protein Neuropeptide Y Receptor Adiposity Mice Knockout Neurons Energy Balance-Obesity Leptin digestive oral and skin physiology Neuropeptide Y receptor humanities 030104 developmental biology nervous system Body Composition Receptors Leptin Female Energy Metabolism Agouti-related peptide hormones hormone substitutes and hormone antagonists |
Zdroj: | Endocrinology. 152:883-889 |
ISSN: | 1945-7170 0013-7227 |
Popis: | Neuropeptide Y (NPY) and agouti-related peptide (AGRP) can produce hyperphagia, reduce energy expenditure, and promote triglyceride deposition in adipose depots. As these two neuropeptides are coexpressed within the hypothalamic arcuate nucleus and mediate a major portion of the obesity caused by leptin signaling deficiency, we sought to determine whether the two neuropeptides mediated identical or complementary actions. Because of separate neuropeptide receptors and signal transduction mechanisms, there is a possibility of distinct encoding systems for the feeding and energy expenditure aspects of leptin-regulated metabolism. We have genetically added NPY deficiency and/or AGRP deficiency to LEPR deficiency isolated to AGRP cells. Our results indicate that the obesity of LEPR deficiency in AGRP/NPY neurons can produce obesity with either AGRP or NPY alone with AGRP producing hyperphagia while NPY promotes reduced energy expenditure. The absence of both NPY and AGRP prevents the development of obesity attributable to isolated LEPR deficiency in AGRP/NPY neurons. Operant behavioral testing indicated that there were no alterations in the reward for a food pellet from the AGRP-specific LEPR deficiency. |
Databáze: | OpenAIRE |
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