Parkinson’s disease: the thalamic components of the limbic loop are severely impaired by α-synuclein immunopositive inclusion body pathology
| Autor: | R. A. I. de Vos, Estifanos Ghebremedhin, K. Del Tredici, Christian Schultz, Udo Rüb, Heiko Braak, E.N.H. Jansen Steur |
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| Rok vydání: | 2002 |
| Předmět: |
Male
Aging Pathology medicine.medical_specialty Tissue Fixation Parkinson's disease Thalamus Central nervous system Synucleins Nerve Tissue Proteins chemistry.chemical_compound Degenerative disease Limbic system Alzheimer Disease Limbic System medicine Humans Aged Inclusion Bodies Alpha-synuclein Amyloid beta-Peptides Lewy body General Neuroscience Parkinson Disease Middle Aged medicine.disease Immunohistochemistry medicine.anatomical_structure nervous system chemistry alpha-Synuclein Synuclein Female Lewy Bodies Autopsy Neurology (clinical) Geriatrics and Gerontology Psychology Neuroscience Developmental Biology |
| Zdroj: | Neurobiology of Aging. 23:245-254 |
| ISSN: | 0197-4580 |
| DOI: | 10.1016/s0197-4580(01)00269-x |
| Popis: | The Parkinson's disease (PD)-related inclusion body pathology comprises Lewy bodies (LBs) as well as Lewy neurites (LNs). The distribution and severity of this pathology were investigated in the thalamus of 12 autopsy cases with clinically diagnosed and neuropathologically confirmed PD. The LBs and LNs were visualized by immunoreactions against the protein alpha-synuclein. In the human thalamus during PD, a specific and highly stereotypical distribution pattern of LBs and LNs evolves. As in cortical and other subcortical regions, the components of human thalamus assigned to the limbic loop bear the brunt of the PD-related pathology. In contrast, the thalamic components integrated into the striatal and cerebellar loops as well as the primary sensory nuclei of the thalamus show at best a mildly developed pathology. Damage to the thalamic components of the limbic loop nuclei may contribute not only to the cognitive, emotional, and autonomic symptoms of PD but to the somatomotor and oculomotor dysfunctions as well. |
| Databáze: | OpenAIRE |
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