Synthesis and Evaluation of Estrogen Receptor Ligands with Bridged Oxabicyclic Cores Containing a Diarylethylene Motif: Estrogen Antagonists of Unusual Structure
| Autor: | John S. Comninos, John A. Katzenellenbogen, Hai-Bing Zhou, Fabio Stossi, Benita S. Katzenellenbogen |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Models
Molecular Transcription Genetic Stereochemistry Estrogen receptor Stereoisomerism In Vitro Techniques Ligands Heptanes Radioligand Assay Structure-Activity Relationship Cell Line Tumor Drug Discovery Estrogen Receptor beta Humans Binding site Structural motif Estrogen receptor beta Binding Sites Molecular Structure Bicyclic molecule Chemistry Uterus Estrogen Receptor alpha Bridged Bicyclo Compounds Heterocyclic Ligand (biochemistry) Endometrial Neoplasms Molecular Medicine Female Estrogen receptor alpha |
| Zdroj: | Journal of Medicinal Chemistry. 48:7261-7274 |
| ISSN: | 1520-4804 0022-2623 |
| DOI: | 10.1021/jm0506773 |
| Popis: | A new series of ligands for the estrogen receptor (ER) based on a three-dimensional structural motif consisting of a bridged oxabicyclic core (7-oxabicyclo[2.2.1]heptene or heptadiene) were synthesized and examined for their receptor binding activity and as regulators of transcription through the two ER subtypes, ER alpha and ER beta. The prototypical ligands also contain a 1,2-diarylethylene motif, common to many nonsteroidal estrogens, as an embellishment on the oxabicyclic core. Thus, these ligands bear peripheral groups typically found in ER ligands, built here upon an overall three-dimensional core topology that is unusual for these targets. Most of these compounds were conveniently synthesized by a Diels-Alder reaction of various 3,4-diarylfurans with a variety of dienophiles, neat and under mild conditions in the absence of catalysts. Some of the synthesized compounds display good binding affinity for the ER, and in transcription assays, the highest affinity compounds are antagonists on both ERs. Molecular modeling studies suggest a structural basis for the antagonist activity of these compounds. These compounds, based on the bicyclo[2.2.1]core system, expand the structural diversity of ligands that can be antagonists for the estrogen receptors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|