Endocrinology and the brain: corticotropin-releasing hormone signaling
| Autor: | Paula A dos Santos Claro, Natalia G Armando, Susana Silberstein, Carolina Inda |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
endocrine system medicine.medical_specialty GPCR endocytosis and signaling Otras Ciencias Biológicas Endocrinology Diabetes and Metabolism Review lcsh:Diseases of the endocrine glands. Clinical endocrinology GPCR Signaling purl.org/becyt/ford/1 [https] Ciencias Biológicas 03 medical and health sciences Corticotropin-releasing hormone CRH system pathophysiology Endocrinology Molecular level cAMP Internal medicine Internal Medicine medicine purl.org/becyt/ford/1.6 [https] Receptor CYCLIC AMP CRH RECEPTOR SIGNALING G protein-coupled receptor lcsh:RC648-665 ERK1/2 business.industry CRH receptors signaling CRH SYSTEM PATHOPHYSIOLOGY Editor's Choice 030104 developmental biology business CIENCIAS NATURALES Y EXACTAS hormones hormone substitutes and hormone antagonists Function (biology) Hormone |
| Zdroj: | Endocrine Connections Endocrine Connections, Vol 6, Iss 6, Pp R99-R120 (2017) CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET |
| ISSN: | 2049-3614 |
| DOI: | 10.1530/ec-17-0111 |
| Popis: | Corticotropin-releasing hormone (CRH) is a key player of basal and stress activated responses in the hypothalamic-pituitary-adrenal axis (HPA) and in extrahypothalamic circuits, where it functions as a neuromodulator to orchestrate humoral and behavioral adaptive responses to stress. This review describes molecular components and cellular mechanisms involved in CRH signaling downstream of its G protein-coupled receptors (GPCRs) CRHR1 and CRHR2, and summarizes recent findings that challenge the classical view of GPCR signaling, and impact on our understanding of CRHRs function. Special emphasis is placed on recent studies of CRH signaling that revealed new mechanistic aspects of cAMP generation and ERK1/2 activation in physiologically relevant contexts of the neurohormone action. In addition, we present an overview of the pathophysiological role of the CRH system, which highlights the need for a precise definition of CRHRs signaling at molecular level to identify novel targets for pharmacological intervention in neuroendocrine tissues and specific brain areas involved in CRH-related disorders. Fil: Inda, María Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina Fil: Armando, Natalia Giannina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; Argentina Fil: Dos Santos Claro, Paula Ayelen. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; Argentina Fil: Silberstein Cuña, Susana Iris. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina |
| Databáze: | OpenAIRE |
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