Grading of Atrophic Gastritis is Useful for Risk Stratification in Endoscopic Screening for Gastric Cancer
| Autor: | Shigekazu Ohyama, Kenji Ohno, Atsushi Hashiba, Kyosuke Kaji, Kenji Yasuda, Yasuo Takeda, Manabu Yoneshima, Chika Uotani, Itasu Ninomiya, Nobu Koyama, Yasushi Yamaguchi, Tokio Wakabayashi, Toshio Ueno, Masato Kiriyama, Ichiro Takabatake, Hisashi Doyama |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Gastritis Atrophic Male medicine.medical_specialty Atrophic gastritis Gastroenterology Helicobacter Infections 03 medical and health sciences 0302 clinical medicine Japan Risk Factors Stomach Neoplasms Internal medicine Gastroscopy medicine Humans Stomach cancer Grading (tumors) Aged Neoplasm Grading Hepatology medicine.diagnostic_test Helicobacter pylori business.industry Stomach Middle Aged medicine.disease Endoscopy medicine.anatomical_structure 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Female Gastritis medicine.symptom Risk assessment business |
| Zdroj: | The American journal of gastroenterology. 114(1) |
| ISSN: | 1572-0241 |
| Popis: | In order to screen for gastric cancer effectively, its interval should be set according to the risk. This study aimed to determine whether risk stratification is possible using the data obtained from medical examination or endoscopic findings.First, subjects who underwent both cancer screening and medical examination from 2009 to 2015 and underwent cancer screening once more by 2016 were studied. Data such as the lipid profile and history of smoking obtained during the medical examination, and the grade of atrophy and presence of peptic ulcers were studied using multivariate analysis. Next, subjects who underwent cancer screening twice or more between 2009 and 2015 with or without medical examinations were studied to analyze any correlation between the grade of atrophy and cancer occurrence using univariate analysis. In both studies, the status of Helicobacter pylori (HP) infection was determined.In the multivariate analysis, 9378 subjects were included. Aging, advanced atrophy, presence of ulcers, and uric acid levels were identified as risk factors. Among subjects who underwent successful HP eradication therapy, advanced atrophy and aging were observed to be crucial risk factors. In the univariate analysis, there were 12,941 subjects. Gastric cancer occurred more frequently in the more severe atrophy group (P0.001). The annual rate of cancer occurrence in the most severe atrophy group was 0.31%, which was approximately thrice as that in the less atrophy group.Risk stratification was possible based on endoscopic examination alone. The interval should be set depending on each case. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|