Sex-specific Associations of Alcohol Withdrawal in Patients Admitted for the Treatment of Alcohol Use Disorder
| Autor: | Paola Zuluaga, Arantza Sanvisens, Fernando Rodríguez de Fonseca, CohRTA study, Daniel Fuster, Roberto Muga, Antoni Short, Antoni Gual, Marta Torrens, Ferran Bolao, Gabriel Rubio |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Alcohol Drinking Alcohol use disorder Logistic regression 01 natural sciences 03 medical and health sciences 0302 clinical medicine Interquartile range Internal medicine medicine Humans Pharmacology (medical) 030212 general & internal medicine 0101 mathematics Family history biology business.industry 010102 general mathematics Odds ratio Middle Aged medicine.disease biology.organism_classification Confidence interval Substance Withdrawal Syndrome Diagnostic and Statistical Manual of Mental Disorders Hospitalization Psychiatry and Mental health Alcoholism Alcohol withdrawal syndrome Female Cannabis business |
| Zdroj: | Journal of addiction medicine. 15(1) |
| ISSN: | 1935-3227 |
| Popis: | OBJECTIVES There are sex differences in the pattern of alcohol consumption and in the complications of alcohol use disorder (AUD). We aimed to identify sex-specific differences in the factors associated with alcohol withdrawal syndrome (AWS) among patients that requested a first treatment for AUD. METHODS We enrolled 313 patients (75% men) with a Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) AUD diagnosis that started treatment between 2014 and 2016. We collected socio-demographics, the type and amount of alcohol and other substances consumed, and clinical and laboratory parameters. According to Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) AUD criteria, AWS occurred when patients experienced 2 or more clinical signs/symptoms and/or consumed alcohol to relieve symptoms. Logistic regression models were used to determine factors associated with AWS according to sex. RESULTS The median age of participants was 50 years (interquartile range [IQR]: 43-54 years). The median age of starting alcohol consumption was 16 years (IQR: 14-18 years). Notably, 69% of participants smoked tobacco, and 61% had a family history of AUD; 18% currently used cannabis, and 7.7% used cocaine. Overall, 73% of patients exhibited AWS criteria, and men (76.5%) were more likely than women (64.6%) to report AWS (P = 0.038). In the adjusted analysis, factors associated with AWS were the age at starting alcohol consumption (odds ratio [OR] for every 5 years = 1.89, 95% confidence interval [CI]: 1.69-2.08), and cannabis use (OR = 2.8, 95% CI: 1.04-7.7) in men, and a family history of AUD in women (OR = 2.85 95% CI: 1.07-7.54). CONCLUSIONS factors associated with AWS differ by sex which may have clinical implications for proactive management of AWS during treatment for AUD. |
| Databáze: | OpenAIRE |
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