Comparison of two oral regimens for the outpatient treatment of low-risk cancer patients with chemotherapy-induced neutropenia and fever: ciprofloxacin plus cefuroxime axetil versus ciprofloxacin plus amoxicillin/clavulanate

Autor:	Nikolaos V. Sipsas, Elias Skopelitis, Nikolaos Tsavaris, A. Karabelis, M. Vadiaka, Panayiotis D. Ziakas, Theodore Kordossis, Christos Kosmas
Rok vydání:	2007
Předmět:	Microbiology (medical) Adult Male medicine.medical_specialty Neutropenia Fever Administration Oral Amoxicillin-Potassium Clavulanate Combination Anti-Infective Agents Ciprofloxacin Internal medicine Neoplasms medicine Ambulatory Care Humans Antibacterial agent Aged Retrospective Studies Cefuroxime Leukopenia General Immunology and Microbiology business.industry General Medicine Bacterial Infections biochemical phenomena metabolism and nutrition Amoxicillin Middle Aged bacterial infections and mycoses medicine.disease Surgery Regimen Infectious Diseases Drug Therapy Combination Female medicine.symptom business Febrile neutropenia medicine.drug
Zdroj:	Scandinavian journal of infectious diseases. 39(9)
ISSN:	0036-5548
Popis:	The objective of this investigation was to assess retrospectively the safety and the efficacy of oral ciprofloxacin plus cefuroxime axetil compared to the combination of oral ciprofloxacin plus amoxicillin/clavulanate, as initial outpatient treatment, in low-risk cancer patients with fever and neutropenia. We analysed retrospectively 120 episodes of febrile neutropenia, treated on an outpatient basis at 2 different oncology units; 63 episodes were treated with the oral regimen of ciprofloxacin plus amoxicillin/clavulanate and 57 were treated with the combination of oral ciprofloxacin plus cefuroxime. 20 treatment failures were recorded-2 of them among patients receiving ciprofloxacin plus amoxicillin/clavulanate and 18 in the ciprofloxacin plus cefuroxime group. Univariate analysis showed that the administration of ciprofloxacin plus cefuroxime was associated with a worse outcome compared to the regimen ciprofloxacin plus amoxicillin/clavulanate (OR 11, CI 2.42-49.9, p =0.002). In the multivariate model, after adjusting for the absolute number of neutrophils and the duration of neutropenia, the effect of the antibiotic regimen on the outcome disappeared, and no significant differences between the 2 regimens were noted, although the regimen of ciprofloxacin plus cefuroxime was associated with a trend to a worse outcome (OR 4.74, CI 0.72-31.1, p =0.10). In conclusion, the 2 regimens appeared equally safe and effective but prospective studies are needed to confirm these results.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95ccf80f415febb782555bb6790ba375 https://pubmed.ncbi.nlm.nih.gov/17701717 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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