Depression in inflammatory bowel disease: risk factor, prodrome or extraintestinal manifestation?
| Autor: | Zahra Mohamedali, Christopher W P Hopkins, Calum D. Moulton, Christine Norton, Nick Powell |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Context (language use) digestive system Inflammatory bowel disease Prodrome 03 medical and health sciences 0302 clinical medicine inflammatory bowel disease Risk Factors Epidemiology Medicine Humans Risk factor Intensive care medicine Depression (differential diagnoses) Gastroenterology & Hepatology business.industry Depression Incidence (epidemiology) Gastroenterology Psychosomatic medicine 1103 Clinical Sciences medicine.disease Inflammatory Bowel Diseases digestive system diseases Antidepressive Agents 030104 developmental biology psychosomatic medicine 1114 Paediatrics and Reproductive Medicine 030211 gastroenterology & hepatology epidemiology business |
| Popis: | We read with interest Frolkis and colleagues’ recent study, in which depression was associated with increased risk of incident IBD in a large primary care database.1 While treatment of depression in IBD has been suggested to improve IBD outcomes,2 this study goes further, suggesting that assertive pharmacological treatment of depression could reduce the incidence of IBD altogether. Despite the study’s manifest strengths, we wish to draw the authors’ attention to an important limitation of its current design that tempers its conclusions. Temporality between exposure and outcome is a key test of causality.3 This is challenging in the context of depression and IBD because their symptoms … |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|