Conductive Composite Fiber with Optimized Alignment Guides Neural Regeneration under Electrical Stimulation
| Autor: | Feihan Li, Jianxun Ding, Xi Zhang, Huanghao Yang, Ziwen Qiao, Liangdan Zeng, He Liu, Zhonghan Wang, Jin Zhang, Chenyu Wang |
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| Rok vydání: | 2020 |
| Předmět: |
Materials science
Polyesters Composite number Biomedical Engineering Pharmaceutical Science 02 engineering and technology Carbon nanotube 010402 general chemistry 01 natural sciences law.invention Biomaterials Contact angle law Ultimate tensile strength Fiber Electrical conductor Tissue Scaffolds Nanotubes Carbon Rotational speed 021001 nanoscience & nanotechnology Electrospinning Electric Stimulation 0104 chemical sciences Nerve Regeneration 0210 nano-technology Biomedical engineering |
| Zdroj: | Advanced healthcare materials. 10(3) |
| ISSN: | 2192-2659 |
| Popis: | Conductivity and alignment of scaffolds are two primary factors influencing the efficacy of nerve repair. Herein, conductive composite fibers composed of poly(ɛ-caprolactone) (PCL) and carbon nanotubes (CNTs) with different orientation degrees are prepared by electrospinning at various rotational speeds (0, 500, 1000, and 2000 rpm), and meanwhile the synergistic promotion mechanism of aligned topography and electrical stimulation on neural regeneration is fully demonstrated. Under an optimized rotational speed of 1000 rpm, the electrospun PCL fiber exhibits orientated structure at macroscopic (mean deviation angle = 2.78°) or microscopic crystal scale (orientation degree = 0.73), decreased contact angle of 99.2° ± 4.9°, and sufficient tensile strength in both perpendicular and parallel directions to fiber axis (1.13 ± 0.15 and 5.06 ± 0.98 MPa). CNTs are introduced into the aligned fiber for further improving conductivity (15.69-178.63 S m-1 ), which is beneficial to the oriented growth of neural cells in vitro as well as the regeneration of injured sciatic nerves in vivo. On the basis of robust cell induction behavior, optimum sciatic nerve function index, and enhanced remyelination/axonal regeneration, such conductive PCL/CNTs composite fiber with optimized fiber alignment may serve as instructive candidates for promoting the scaffold- and cell-based strategies for neural repair. |
| Databáze: | OpenAIRE |
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