Potential of iodine-123 metaiodobenzylguanidine single-photon emission tomography to detect abnormal functional status of the pulmonary neuroadrenergic system in irradiated lung
| Autor: | Norihiko Kume, Kazuya Nishigauchi, Kensaku Shimizu, Akiko Hara, Kazuyoshi Suga, Naofumi Matsunaga, Kazumi Motoyama |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
Lung Neoplasms Sympathetic Nervous System Single-photon emission computed tomography Lung injury Iodine Radioisotopes Iodine-123 medicine Humans Radiology Nuclear Medicine and imaging Lung cancer Lung Aged Tomography Emission-Computed Single-Photon medicine.diagnostic_test business.industry Respiratory disease General Medicine medicine.disease 3-Iodobenzylguanidine medicine.anatomical_structure Case-Control Studies Female Radiopharmaceuticals Nuclear medicine business Perfusion Emission computed tomography |
| Zdroj: | European Journal of Nuclear Medicine and Molecular Imaging. 26:647-654 |
| ISSN: | 1619-7089 1619-7070 |
| DOI: | 10.1007/s002590050433 |
| Popis: | The potential of iodine-123 metaiodobenzylguanidine (MIBG) to detect functional abnormalities of the pulmonary neuroadrenergic system (PNS) in irradiated lung areas (ILAS) was preliminarily explored using single-photon emission tomography (SPET). The subjects included five healthy subjects and a total of 31 patients with peripheral-type lung cancer treated by radiation; 15 patients (group A) had received a dose of less than 36 Gy (mean +/- SD: 28.2 +/-6.2 Gy), and 16 patients (group B) had received a higher dose (mean +/- SD: 51.2 +/- 3.5 Gy) at the time of examination. MIBG SPET scans acquired 15 min and 3 h after injection were used to measure the MIBG uptake ratio (count ratio of the ILA to the contralateral non-ILA) and the clearance rate [percentage of (early counts - delayed counts)/early counts] from the ILAs without noticeable abnormal opacities on chest computed tomography scan. Lung perfusion changes were also assessed by technetium-99m macroaggregated albumin SPET. By contrast to the homogeneous MIBG uptake in the lungs of the healthy subjects, MIBG uptake was folcally decreased in correspondence with the ILAs in all patients, including 11 patients (73.3%) of group A with relatively preserved lung perfusion. The reduction MIBG uptake was significant (P0.0001), and the MIBG clearance rate from the ILAs was also significantly faster than the clearance rates from the normal lungs and contralateral non-ILAs (both P0.01). Group B patients showed significantly lower MIBG uptake and faster clearance from the ILAs than group A patients (P0. 001 and P0.05, respectively), although there was no significant difference in the clearance from the non-ILAs. Overall, MIBG uptake/clearance from the ILAs correlated significantly with the radiation dose in the 31 patients (r = -0.656; P0.0001 and r = 0. 387; P0.05, respectively). Perfusion changes were inversely correlated with the clearance from the ILAs (r = -0.432, P0.05), but did not correlate with MIBG uptake. These preliminary results suggest that MIBG may have the potential to be a marker of abnormal functional status of the PNS produced by irradiation and may facilitate investigation of irradiation lung injury independently of morphological or lung perfusion changes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|