Radical radiotherapy for paediatric solid tumour metastases: An overview of current European protocols and outcomes of a SIOPE multicenter survey

Autor: Lorenza Gandola, Stéphane Supiot, Aikaterini Alexopoulou, Semi Harrabi, Beate Timmermann, Henry Mandeville, Marzanna Chojnacka, Stéphanie Bolle, A. Napieralska, Giovanni Scarzello, Candan Demiröz Abakay, Anna Mussano, Jelena Bokun, Petra S. Kroon, Sophie C. Huijskens, Jordi Giralt, Geert O. Janssens, John H. Maduro, Laetitia Padovani, Mark N. Gaze, Line Claude, Alexandre Escande, Enrica Seravalli
Přispěvatelé: Guided Treatment in Optimal Selected Cancer Patients (GUTS), Institut Català de la Salut, [Huijskens SC, Kroon PS] Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, The Netherlands. [Gaze MN] Department of Oncology, University College London Hospitals, London, UK. [Gandola L] Paediatric Radiotherapy Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. [Bolle S] Department of Radiation Oncology, Gustave Roussy, Villejuif, France. [Supiot S] Oncologie Radiotherapie, Institut de Cancérologie de l’Ouest, Nantes, France. [Giralt J] Servei d’Oncologia Radioteràpica, Vall d’Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus
Rok vydání: 2020
Předmět:
0301 basic medicine
Cancer Research
medicine.medical_treatment
Medizin
Renal tumours
Therapeutics::Radiotherapy [ANALYTICAL
DIAGNOSTIC AND THERAPEUTIC TECHNIQUES
AND EQUIPMENT]
Metastases
Neuroblastoma
0302 clinical medicine
Neoplasms
Rhabdomyosarcoma
Neoplasm Metastasis
Practice Patterns
Physicians'
Radiation treatment planning
Stage IV
Càncer - Radioteràpia
Soft tissue sarcoma
Neoplasms::Neoplastic Processes::Neoplasm Metastasis [DISEASES]
SIOPE
Age Factors
Europe
Treatment Outcome
Oncology
030220 oncology & carcinogenesis
Practice Guidelines as Topic
Soft-tissue sarcoma
Sarcoma
Radiology
medicine.medical_specialty
Radiosurgery
epidemiología y bioestadística::epidemiología::usos de la epidemiología::evaluación del resultado de intervenciones terapéuticas [SALUD PÚBLICA]
03 medical and health sciences
Metàstasi
terapéutica::radioterapia [TÉCNICAS Y EQUIPOS ANALÍTICOS
DIAGNÓSTICOS Y TERAPÉUTICOS]
medicine
Humans
Healthcare Disparities
Solid tumour
Neuroblasoma
Radiotherapy
business.industry
Radical radiotherapy
Paediatrics
medicine.disease
Radiation therapy
Epidemiology and Biostatistics::Epidemiology::Uses of Epidemiology::Evaluation of Results of Therapeutic Interventions [PUBLIC HEALTH]
030104 developmental biology
neoplasias::procesos neoplásicos::metástasis neoplásica [ENFERMEDADES]
Health Care Surveys
Multicenter survey
Avaluació de resultats (Assistència sanitària)
Dose Fractionation
Radiation
business
Ewing sarcoma
Zdroj: European Journal of Cancer, 145, 121-131. ELSEVIER SCI LTD
Scientia
ISSN: 1879-0852
0959-8049
Popis: Metàstasis; Pediatria; Radioteràpia Metástasis; Pediatría; Radioterapia Metastases; Paediatrics; Radiotherapy Purpose/objective About 20% of children with solid tumours (ST) present with distant metastases (DM). Evidence regarding the use of radical radiotherapy of these DM is sparse and open for personal interpretation. The aim of this survey was to review European protocols and to map current practice regarding the irradiation of DM across SIOPE-affiliated countries. Materials/methods Radiotherapy guidelines for metastatic sites (bone, brain, distant lymph nodes, lung and liver) in eight European protocols for rhabdomyosarcoma, non-rhabdomyosarcoma soft-tissue sarcoma, Ewing sarcoma, neuroblastoma and renal tumours were reviewed. SIOPE centres irradiating ≥50 children annually were invited to participate in an online survey. Results Radiotherapy to at least one metastatic site was recommended in all protocols, except for high-risk neuroblastoma. Per protocol, dose prescription varied per site, and information on delineation and treatment planning/delivery was generally missing. Between July and September 2019, 20/27 centres completed the survey. Around 14% of patients were deemed to have DM from ST at diagnosis, of which half were treated with curative intent. A clear cut-off for a maximum number of DM was not used in half of the centres. Regardless of the tumour type and site, conventional radiotherapy regimens were most commonly used to treat DM. When stereotactic radiotherapy was used, a wide range of fractionation regimens were applied. Conclusion Current radiotherapy guidelines for DM do not allow a consistent approach in a multicentre setting. Prospective (randomised) trials are needed to define the role of radical irradiation of DM from paediatric ST. Stichting Kinderen Kankervrij [project no. 343]. KiKa (Children Cancer Free) foundation, grant number 343 and title: Towards optimization of radiotherapy techniques for metastatic lesions in children stage IV disease. The funding source had no role in the study design, collection, analysis and interpretation of data, writing of this manuscript or the decision to submit the article for publication.
Databáze: OpenAIRE
Externí odkaz: