Exposure to PFAS and small for gestational age new-borns: A birth records study in Veneto Region (Italy)
| Autor: | Francesca Russo, Silvia Manea, Marco Martuzzi, Domenico Mantoan, Giulia Lorenzoni, Monica Mazzucato, Paola Facchin, Tony Fletcher, L. Salmaso |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Multivariate analysis
Perfluoroalkylated substances Birth weight PFAS small for gestational age SGA fetal growth Gestational Age 010501 environmental sciences 01 natural sciences Biochemistry 03 medical and health sciences 0302 clinical medicine Risk Factors Environmental health medicine Fetal growth Humans 030212 general & internal medicine Risk factor 0105 earth and related environmental sciences General Environmental Science Retrospective Studies Fluorocarbons business.industry Infant Newborn Gestational age Retrospective cohort study Stepwise regression medicine.disease Italy Birth Certificates Infant Small for Gestational Age Small for gestational age Female business |
| Zdroj: | Environmental research. 184 |
| ISSN: | 1096-0953 |
| Popis: | Background Perfluoroalkylated substances (PFAS) in serum are inversely associated with fetal growth. Small for gestational age (SGA) is a measure based on birth weight and gestational age at birth and represents a good indicator of fetal growth but it has been used only in a small number of studies. We examined the association between PFAS exposure and the risk of severe SGA in a PFAS contaminated area in the Veneto Region (North-East of Italy). Methods A retrospective cohort study has been developed including all singleton live births reported in the Veneto Region Birth Registry between 2003 and 2018 to mothers living in the contaminated and in a control area. We estimated the association between mothers’ area of residence and severe SGA using crude RR (and 95% CI) and stepwise logistic regression, including all the maternal characteristics. Results The study included 105,114 singleton live births. The occurence of severe SGA was 3.44% in the contaminated area and 2.67% in the control area. The multivariate analysis confirmed that living in the contaminated area significantly increased the odds of severe SGA (adjusted OR 1.27 (95% C.I. 1.16, 1.39)). Conclusions The findings suggest that living in a contaminated area by PFAS plays a role in affecting fetal growth and support the hypothesis that PFAS exposure is a risk factor for SGA. Individual data on exposure are needed to confirm the direct association. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect