Tolerability and pharmacokinetics of remoxipride after intramuscular administration
| Autor: | A. Zaar-Hedin, W. Yisak, M. Laxenaire, L. Nilsson, J.-P. Kahn, C. Albaret |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
Male Adolescent Linear kinetics Cmax Injections Intramuscular Pharmacokinetics Remoxipride medicine Humans Psychiatric Status Rating Scales Dose-Response Relationship Drug business.industry Significant difference Middle Aged Psychiatry and Mental health Tolerability Repeated doses Anesthesia Benzamides Plasma concentration Schizophrenia Female Schizophrenic Psychology business Antipsychotic Agents medicine.drug |
| Zdroj: | Acta Psychiatrica Scandinavica. 82:51-53 |
| ISSN: | 1600-0447 0001-690X |
| Popis: | A study was undertaken in seven schizophrenic patients to evaluate the tolerability and examine the pharmacokinetics of intramuscularly administered remoxipride after a single 200 mg dose and at steady state following repeated doses of 200 mg twice daily for one week. Comparisons of AUC, t1/2 and tmax using the Wilcoxon's signed rank test showed no significant difference between single dose and steady state indicating that the pharmacokinetics of intramuscular remoxipride were linear. The steady-state Cmax was found to be significantly larger than that after single dose and the increase was accounted for by the predicted accumulation factor, assuming linear kinetics. Although the inter-individual variability in plasma concentrations was large, the intra-individual variability was low as shown by the reproducibility of the single-dose and steady-state plasma curves. Remoxipride, administered intramuscularly, was well tolerated. |
| Databáze: | OpenAIRE |
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