Do low-serum vitamin E levels increase the risk of Alzheimer disease in older people? Evidence from a meta-analysis of case-control studies
| Autor: | Yan Shu, Meng Li, Xiaodan Chen, Yonghai Dong, Xihong Guan, Ting Chen, Lei Xu, Yun Liu |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Gerontology China medicine.medical_specialty Funnel plot medicine.medical_treatment 03 medical and health sciences 0302 clinical medicine Alzheimer Disease Risk Factors Internal medicine Forest plot Humans Vitamin E Medicine Prospective Studies Prospective cohort study Aged business.industry Case-control study Publication bias Confidence interval Psychiatry and Mental health 030104 developmental biology Case-Control Studies Meta-analysis Geriatrics and Gerontology business 030217 neurology & neurosurgery |
| Zdroj: | International Journal of Geriatric Psychiatry. 33:e257-e263 |
| ISSN: | 0885-6230 |
| DOI: | 10.1002/gps.4780 |
| Popis: | Objective Whether low-serum vitamin E increases the risk of Alzheimer disease (AD) in older people remains inconclusive. This meta-analysis aims to synthesize evidence-based case-control studies to evaluate the association between serum vitamin E and the risk of AD. Methods Potentially relevant studies were selected through PubMed, Embase, Wanfang, Chongqing VIP, and China National Knowledge Infrastructure databases by using the core terms Vitamin E/alpha-tocopherol and Alzheime's disease/senile dementia/AD in the titles, abstracts, and keywords of the articles. The association between serum vitamin E levels and AD was estimated by using the weighted mean difference (WMD) and 95% confidence interval by adopting a random effects model. Heterogeneity was assessed by using Cochran Q test and I2 statistic. Forest plot was used to present the results graphically from meta-analysis. Publication bias was evaluated by using funnel plots and Egger test. Results We identified 17 studies that met the eligibility criteria. The studies included 2057 subjects with 904 AD patients and 1153 controls. The results indicated that AD patients had a lower concentration of serum vitamin E compared with healthy controls among older people (WMD = −6.811 μmol/L, 95% confidence interval −8.998 to −4.625; Z = −6.105, P |
| Databáze: | OpenAIRE |
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