Pacemaker Process of Ureteral Peristalsis in Multicalyceal Kidneys
| Autor: | Wolfgang Lutzeyer, Josef Hannappel, Klaus Golenhofen, Joachim Hohnsbein |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Epinephrine
Swine Urology Ureteral peristalsis urologic and male genital diseases Kidney Calices Membrane Potentials chemistry.chemical_compound Ureter Animals Medicine Kidney Pelvis Tetraethylammonium business.industry Muscle Smooth Anatomy Tetraethylammonium Compounds Coupling ratio Intercellular Junctions medicine.anatomical_structure chemistry Fast activity medicine.symptom business Renal pelvis Muscle Contraction Muscle contraction |
| Zdroj: | Urologia Internationalis. 37:240-246 |
| ISSN: | 1423-0399 0042-1138 |
| DOI: | 10.1159/000280826 |
| Popis: | The mechanical activity of isolated strips from different areas of the pyeloureteral system was investigated in 10 pigs: calyx, renal pelvis, pyeloureteral junction and ureter. Additionally, electrical activity was measured in some pyeloureteral preparations using the sucrose-gap technique. Regular spontaneous activity with an average frequency of 9.5/min was recorded in calyceal strips, decreasing to 5.4/min in renal pelvis, 5.7/min in pyeloureteral preparations and to 1.2/min in ureteral preparations. The activity of renal pelvis, pyeloureteral and ureteral preparations was less regular, and bursts of fast activity (near 10/min) could be observed in all these preparations. The membrane potential of pyeloureteral strips showed spontaneous generator oscillations of about 10/min. Variations in the pattern of ureteral peristalsis are due to different coupling ratios of membrane potential oscillations to contractions. Adrenaline (10(-5) mol/l) increased the frequency of the oscillations and enhanced their manifestation in the mechanical recordings, whereas tetraethylammonium (5-20 mmol/l) only increased the coupling ratio. The following concept for the generation of ureteral peristalsis in multicalyceal kidneys is developed: several (primary) oscillators exist in the calyces; in the pyeloureteral junction a (secondary) pacemaker exists which has an intrinsic frequency similar to that of the calyceal pacemakers; both processes cooperate in the generation of ureteral peristalsis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|