Melaleuca alternifolia (tea tree) oil and its monoterpene constituents in treating protozoan and helminthic infections
| Autor: | Nelson Siukei Lam, Fangli Lu, Xin-zhuan Su, Xinxin Long |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Nematodes Antiprotozoal Agents Helminthiasis RM1-950 Monogenean parasites Microbiology 03 medical and health sciences 0302 clinical medicine Tea Tree Oil parasitic diseases medicine Animals Humans Protozoa Pharmacology Protozoan Infections Ichthyophthirius multifiliis biology Host (biology) Anisakis simplex Tea tree oil Melaleuca alternifolia General Medicine biology.organism_classification Melaleuca 030104 developmental biology 030220 oncology & carcinogenesis Trypanosoma Anti-Infective Agents Local Monoterpenes Acanthamoeba castellanii Therapeutics. Pharmacology Cestode medicine.drug Haemonchus contortus |
| Zdroj: | Biomedicine & Pharmacotherapy, Vol 130, Iss, Pp 110624-(2020) |
| ISSN: | 1950-6007 |
| Popis: | Australian tea tree (Melaleuca alternifolia) oil (TTO) and its monoterpene constituents such as terpinen-4-ol (T4O), 1,8-cineole, limonene, p-cymene, and α-terpinene have been shown to be effective in controlling a wide range of parasitic infections. The anti-parasitic effects of these compounds are mainly due to their anti-histamine and anti-acetylcholinesterase activities as well as their ability to modulate host inflammatory responses. This review attempts to summarize recent advances in the uses of TTO and its 15 major monoterpene constituents in treating parasitic infections in both humans and animals. Activities against parasitic protozoans (Plasmodium falciparum, Leishmania spp., Trypanosoma spp., Acanthamoeba castellanii, Trichomonas vaginalis, Eimeria, and Ichthyophthirius multifiliis), nematodes (Haemonchus contortus and Anisakis simplex), cestode (Echinococcus ortleppi), and monogeneans (Gasterosteus spp. and Dactylogyrus minutus) have been reported, showing good potentials in treating parasitic infections. Further studies are necessary for developing anti-parasite therapies using TTO or its monoterpenes constituents. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect