Speech metrics, general disability, brain imaging and quality of life in multiple sclerosis
| Autor: | Jim Stankovich, Adam P. Vogel, Thushara Perera, Andrew Evans, A. Van der Walt, Frederique M.C. Boonstra, Gustavo Noffs, Scott C Kolbe, Helmut Butzkueven, Mary P. Galea, L Euardo Cofre Lizama, Fernanda Maldonado |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Multiple Sclerosis medicine.medical_treatment Neuroimaging Audiology Disability Evaluation 03 medical and health sciences Dysarthria 0302 clinical medicine Quality of life otorhinolaryngologic diseases medicine Humans Speech 030212 general & internal medicine Rehabilitation Expanded Disability Status Scale business.industry Multiple sclerosis Neuropsychology Brain medicine.disease Magnetic Resonance Imaging Benchmarking Neurology Brain size Quality of Life Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | European Journal of Neurology. 28:259-268 |
| ISSN: | 1468-1331 1351-5101 |
| Popis: | BACKGROUND AND PURPOSE: Objective measurement of speech has shown promising results to monitor disease state in multiple sclerosis. In this study, we characterize the relationship between disease severity and speech metrics through perceptual (listener based) and objective acoustic analysis. We further look at deviations of acoustic metrics in people with no perceivable dysarthria. METHODS: Correlations and regression were calculated between speech measurements and disability scores, brain volume, lesion load and quality of life. Speech measurements were further compared between three subgroups of increasing overall neurological disability: mild (as rated by the Expanded Disability Status Scale ≤2.5), moderate (≥3 and ≤5.5) and severe (≥6). RESULTS: Clinical speech impairment occurred majorly in people with severe disability. An experimental acoustic composite score differentiated mild from moderate (P |
| Databáze: | OpenAIRE |
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