Comparison of CGM-Derived Measures of Glycemic Variability Between Pancreatogenic Diabetes and Type 2 Diabetes Mellitus
| Autor: | Atluri Sridevi, Shah Kejal, Yalamanchi Aiswarya, Premchander Aarudhra, Biswas Anupam, Barure Ramdas, Kolla Gautham, C Shivaprasad |
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| Rok vydání: | 2019 |
| Předmět: |
Blood Glucose
medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism Biomedical Engineering Bioengineering Type 2 diabetes Hypoglycemia Gastroenterology Fibrocalculous pancreatic diabetes Internal medicine Internal Medicine medicine Humans Glycemic Glycated Hemoglobin Continuous glucose monitoring business.industry Blood Glucose Self-Monitoring nutritional and metabolic diseases Type 2 Diabetes Mellitus Original Articles medicine.disease Diabetes Mellitus Type 2 business Pancreatogenic diabetes |
| Zdroj: | J Diabetes Sci Technol |
| ISSN: | 1932-2968 |
| DOI: | 10.1177/1932296819860133 |
| Popis: | Background: To compare glycemic variability (GV) indices between patients with fibrocalculous pancreatic diabetes (FCPD) and type 2 diabetes mellitus (T2D) using continuous glucose monitoring (CGM). Methods: We measured GV indices using CGM (iPro™2 Professional CGM, Medtronic, USA) data in 61 patients each with FCPD and T2D who were matched for glycated hemoglobin A1c (HbA1c) and duration of diabetes. GlyCulator2 software was used to estimate the CGM-derived measures of GV (SD, mean amplitude of glycemic excursion [MAGE], continuous overall net glycemic action [CONGA], absolute means of daily differences [MODD], M value, and coefficient of variance [%CV]), hypoglycemia (time spent below 70 mg/dL, AUC below 70 mg/dL, glycemic risk assessment diabetes equation hypoglycemia, Low Blood Glucose Index), and hyperglycemia (time spent above 180 mg/dL at night [TSA > 180], AUC above 180 mg/dL [AUC > 180], glycemic risk assessment diabetes equation hyperglycemia, High Blood Glucose Index [HBGI], and J index). The correlation of GV indices with HbA1c, duration of diabetes, and demographic and biochemical parameters were also assessed. Results: All the CGM-derived measures of GV (SD, MAGE, CONGA, MODD, and %CV), except M value, were significantly higher in the FCPD group than in the T2D group ( P < 0.05). Measures of hyperglycemia (TSA >180, AUC >180, HBGI, and J index) were significantly higher in the FCPD group than in the T2D group ( P < 0.05). The measures of hypoglycemia were not significantly different between the two groups. All the hyperglycemia indices showed a positive correlation with HbA1c in both groups. Conclusions: FCPD is associated with higher GV than is T2D. The findings of higher postprandial glycemic excursions in patients with FCPD could have potential therapeutic implications. |
| Databáze: | OpenAIRE |
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