Hepatitis B virus and other transfusion-transmissible infections in child blood recipients in Lao People’s Democratic Republic: a hospital-based study
| Autor: | Vilaysone Khounvisith, Sonephet Saysouligno, Bounpalisone Souvanlasy, Somxay Billamay, Sodaly Mongkhoune, Bounta Vongphachanh, Chantal J Snoeck, Antony P Black, Claude P Muller, Judith M Hübschen |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Archives of Disease in Childhood. 108:15-19 |
| ISSN: | 1468-2044 0003-9888 |
| Popis: | IntroductionChildren requiring multiple blood transfusions are at high risk of transfusion-transmissible infections (TTIs). Lao People’s Democratic Republic is a low-resource setting where donor blood screening faces challenges. This study aimed to determine the burden of TTIs in children in Vientiane Capital.Methods300 children with transfusion history and 300 controls were recruited. In addition, 49 newly diagnosed transfusion recipients were followed for up to 12 months. Serum was tested for hepatitis B surface antigen and IgG antibodies against parvovirus B19, hepatitis B, C and E viruses.ResultsThe patients had a similar prevalence of anti-hepatitis B core antibodies (56; 18.7%) and hepatitis B surface antigen (8; 2.7%) as the controls (58; 19.3% and 9; 3.0%, respectively). However, there was a higher prevalence of an antibody profile suggestive of hepatitis B vaccination (anti-hepatitis B surface antibody positive/anti-hepatitis B core antibody negative) in the transfused group (140/299; 46.8%) than in controls (77/300; 25.7%, pConclusionOur results suggest no significant role of TTIs in Lao children. The higher prevalence of the hepatitis B vaccination profile in transfusion recipients showed that recommendations to vaccinate before commencing transfusions is at least partially implemented, although there is room for improvement. |
| Databáze: | OpenAIRE |
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