Randomized Controlled Trial of DHA Supplementation during Pregnancy: Child Adiposity Outcomes

Autor: Benjamin Larsen, Elia Escaname, Theresa L. Powell, Sartaj K. Siddiqui, Byron A. Foster, Rajam S. Ramamurthy, John Menchaca, Christian A. Aquino, Daniel E. Hale
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
obesity
nutrient supplementation
Body Mass Index
law.invention
Child Development
Randomized controlled trial
Pregnancy
law
docosahexaenoic acid
pregnancy
children
Adiposity
2. Zero hunger
Arachidonic Acid
Nutrition and Dietetics
Pregnancy Outcome
3. Good health
Gestational diabetes
Breast Feeding
Child
Preschool
Gestation
Female
Adult
medicine.medical_specialty
Docosahexaenoic Acids
Offspring
Mothers
Gestational Age
Placebo
Article
Young Adult
03 medical and health sciences
Double-Blind Method
Internal medicine
medicine
Humans
030109 nutrition & dietetics
business.industry
Infant
Maternal Nutritional Physiological Phenomena
medicine.disease
Obesity
Diet
Diabetes
Gestational
Nutrition Assessment
Endocrinology
Socioeconomic Factors
Dietary Supplements
business
Body mass index
Follow-Up Studies
Food Science
Zdroj: Nutrients; Volume 9; Issue 6; Pages: 566
Nutrients
ISSN: 2072-6643
DOI: 10.3390/nu9060566
Popis: Investigating safe and effective interventions in pregnancy that lower offspring adiposity is important given the burden of obesity and subsequent metabolic derangements. Our objective was to determine if docosahexaenoic acid (DHA) given during pregnancy to obese mothers results in lower offspring adiposity. This study was a long-term follow-up of a randomized trial of mothers with gestational diabetes or obesity who were randomized to receive DHA supplementation at 800 mg/day or placebo (corn/soy oil) starting at 25–29 weeks gestation. Anthropometric measures were collected at birth and maternal erythrocyte DHA and arachidonic (AA) levels were measured at 26 and 36 weeks gestation. At two- and four-year follow-up time points, offspring adiposity measures along with a diet recall were assessed. A significant increase in erythrocyte DHA levels was observed at 36 weeks gestation in the supplemented group (p < 0.001). While no significant differences by measures of adiposity were noted at birth, two or four years by randomization group, duration of breastfeeding (p < 0.001), and DHA level at 36 weeks (p = 0.002) were associated with body mass index z-score. Our data suggest that DHA supplementation during pregnancy in obese mothers may have long-lasting effects on offspring measures of adiposity.
Databáze: OpenAIRE
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