Randomized Controlled Trial of DHA Supplementation during Pregnancy: Child Adiposity Outcomes
Autor: | Benjamin Larsen, Elia Escaname, Theresa L. Powell, Sartaj K. Siddiqui, Byron A. Foster, Rajam S. Ramamurthy, John Menchaca, Christian A. Aquino, Daniel E. Hale |
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Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
obesity nutrient supplementation Body Mass Index law.invention Child Development Randomized controlled trial Pregnancy law docosahexaenoic acid pregnancy children Adiposity 2. Zero hunger Arachidonic Acid Nutrition and Dietetics Pregnancy Outcome 3. Good health Gestational diabetes Breast Feeding Child Preschool Gestation Female Adult medicine.medical_specialty Docosahexaenoic Acids Offspring Mothers Gestational Age Placebo Article Young Adult 03 medical and health sciences Double-Blind Method Internal medicine medicine Humans 030109 nutrition & dietetics business.industry Infant Maternal Nutritional Physiological Phenomena medicine.disease Obesity Diet Diabetes Gestational Nutrition Assessment Endocrinology Socioeconomic Factors Dietary Supplements business Body mass index Follow-Up Studies Food Science |
Zdroj: | Nutrients; Volume 9; Issue 6; Pages: 566 Nutrients |
ISSN: | 2072-6643 |
DOI: | 10.3390/nu9060566 |
Popis: | Investigating safe and effective interventions in pregnancy that lower offspring adiposity is important given the burden of obesity and subsequent metabolic derangements. Our objective was to determine if docosahexaenoic acid (DHA) given during pregnancy to obese mothers results in lower offspring adiposity. This study was a long-term follow-up of a randomized trial of mothers with gestational diabetes or obesity who were randomized to receive DHA supplementation at 800 mg/day or placebo (corn/soy oil) starting at 25–29 weeks gestation. Anthropometric measures were collected at birth and maternal erythrocyte DHA and arachidonic (AA) levels were measured at 26 and 36 weeks gestation. At two- and four-year follow-up time points, offspring adiposity measures along with a diet recall were assessed. A significant increase in erythrocyte DHA levels was observed at 36 weeks gestation in the supplemented group (p < 0.001). While no significant differences by measures of adiposity were noted at birth, two or four years by randomization group, duration of breastfeeding (p < 0.001), and DHA level at 36 weeks (p = 0.002) were associated with body mass index z-score. Our data suggest that DHA supplementation during pregnancy in obese mothers may have long-lasting effects on offspring measures of adiposity. |
Databáze: | OpenAIRE |
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