Pharmacological Blockade of PPARα Exacerbates Inflammatory Pain-Related Impairment of Spatial Memory in Rats
| Autor: | Mehnaz I Ferdousi, Michelle Roche, Catherine B. Healy, Jessica C. Gaspar, David P. Finn |
|---|---|
| Přispěvatelé: | Conselho Nacional de Pesquisa (CNPq)—Brazil |
| Rok vydání: | 2021 |
| Předmět: |
cognition
Elevated plus maze QH301-705.5 complete Freund adjuvant Medicine (miscellaneous) Peroxisome proliferator-activated receptor Endogeny Pharmacology Article General Biochemistry Genetics and Molecular Biology Open field Medicine peroxisome-proliferator activated receptor Biology (General) Receptor Transcription factor chemistry.chemical_classification business.industry OEA PEA Antagonist spatial memory anxiety Blockade chemistry business dorsal hippocampus |
| Zdroj: | Biomedicines Volume 9 Issue 6 Biomedicines, Vol 9, Iss 610, p 610 (2021) |
| ISSN: | 2227-9059 |
| DOI: | 10.3390/biomedicines9060610 |
| Popis: | Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors that exist in three isoforms: PPAR¿, PPARß/¿ and PPAR¿. Studies suggest that the PPAR signalling system may modulate pain, anxiety and cognition. The aim of the present study was to investigate whether endogenous signalling via PPARs differentially modulates innate anxiety responses and mnemonic function in the presence and absence of inflammatory pain. We examined the effects of intraperitoneal administration of GW6471 (PPAR¿ antagonist), GSK0660 (PPARß/¿ antagonist), GW9662 (PPAR¿ antagonist), and N-palmitoylethanolamide (PEA) on rat behaviour in the elevated plus maze (EPM), open field (OF), light-dark box (LDB), and novel object recognition (NOR) tests in the presence or absence of chronic inflammatory pain. Complete Freund's Adjuvant (CFA)-injected rats exhibited impaired recognition and spatial mnemonic performance in the NOR test and pharmacological blockade of PPAR¿ further impaired spatial memory in CFA-treated rats. N-oleoylethanolamide (OEA) levels were higher in the dorsal hippocampus in CFA-injected animals compared to their counterparts. The results suggest a modulatory effect of CFA-induced chronic inflammatory pain on cognitive processing, but not on innate anxiety-related responses. Increased OEA-PPAR¿ signalling may act as a compensatory mechanism to preserve spatial memory function following CFA injection. This research was funded by Conselho Nacional de Pesquisa (CNPq)—Brazil (#207530/2014- 9). JCG was funded by a PhD scholarship from Conselho Nacional de Pesquisa (CNPq)—Brazil. peer-reviewed |
| Databáze: | OpenAIRE |
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