cAMP and extrarenal vasopressin V2 receptors in dogs
| Autor: | J. F. Liard |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
Agonist Receptors Vasopressin Cardiac output Vasopressin medicine.medical_specialty Epinephrine Physiology medicine.drug_class Oxytocin Inferior vena cava Norepinephrine Dogs Physiology (medical) Internal medicine Cyclic AMP medicine Animals Deamino Arginine Vasopressin biology business.industry Fissipedia Hemodynamics biology.organism_classification Adenosine Endocrinology medicine.vein Cardiology and Cardiovascular Medicine business hormones hormone substitutes and hormone antagonists medicine.drug Antidiuretic |
| Zdroj: | American Journal of Physiology-Heart and Circulatory Physiology. 263:H1888-H1891 |
| ISSN: | 1522-1539 0363-6135 |
| DOI: | 10.1152/ajpheart.1992.263.6.h1888 |
| Popis: | The effect of vasopressin analogues on plasma adenosine 3',5'-cyclic monophosphate (cAMP) concentration was examined in a group of five conscious dogs instrumented for the measurement of arterial pressure and cardiac output (electromagnetic flowmeter). These dogs were infused for 20 min with a selective antidiuretic (V2) agonist, desamino-8-D-arginine vasopressin (DDAVP, 10 ng.kg-1 x min-1). This infusion was repeated on another day in the presence of the combined V1-V2 antagonist d(CH2)5-D-Tyr(Et)-4-valine,8-arginine vasopressin. The dogs also received an infusion of the selective V1 agonist 2-phenylalanine,8-ornithine oxytocin (Phe-OrnOT) at a rate of 10 ng.kg-1 x min-1. The effect of these infusions was compared with those of an isotonic saline infusion. Plasma cAMP measured in the aorta remained unchanged during all infusions but that of the selective V2 agonist DDAVP alone, during which it increased significantly from 22.4 +/- 0.8 to 32.6 +/- 4.6 and 37.0 +/- 4.1 pmol/ml after 10 and 20 min, respectively. In the plasma sampled from the inferior vena cava caudal to the renal veins, cAMP increased during DDAVP infusion from 22.2 +/- 2.5 to 39.2 +/- 3.8 and 36.0 +/- 4.0 pmol/ml after 10 and 20 min, respectively. The infusion of DDAVP was later given to the same dogs under anesthesia after bilateral nephrectomy, which did not modify the effect of DDAVP on arterial plasma cAMP. In another group of four conscious dogs, infusion of DDAVP at the same rate did not induce significant changes in plasma catecholamines.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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