Endovascular Treatment of Anterior Circulation Aneurysms With the p64 Flow Modulation Device: Mid- and Long-Term Results in 617 Aneurysms From a Single Center
| Autor: | Hans Henkes, Hansjörg Bäzner, Christina Wendl, Carmen Serna Candel, Oliver Ganslandt, Elina Henkes, Victoria Hellstern, Marta Aguilar Pérez |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Neuros/4 medicine.medical_treatment AcademicSubjects/MED00930 Neuros/3 Medizin Fusiform Aneurysm Single Center Flow diverter stent Aneurysm Occlusion Neurosurgery 20/20: Concise Clear Content medicine Humans Case Series Endovascular treatment cardiovascular diseases ComputingMethodologies_COMPUTERGRAPHICS Retrospective Studies business.industry Endovascular Procedures p64 Flow Modulation Device Anterior circulation aneurysm Flow diversion Intracranial Aneurysm Long term results Clipping (medicine) Middle Aged medicine.disease Embolization Therapeutic Concomitant cardiovascular system Surgery Female Stents Neurology (clinical) Radiology business Intracranial aneurysms |
| Zdroj: | Operative Neurosurgery Neurosurgery |
| ISSN: | 2332-4260 |
| Popis: | BACKGROUND Flow diverters have become an important tool in the treatment of intracranial aneurysms, especially when dealing with difficult-to-treat or complex aneurysms. The p64 is the only fully resheathable and mechanically detachable flow diverter available for clinical use. OBJECTIVE To evaluate the safety and effectiveness of p64 for the treatment of intracranial saccular unruptured aneurysms arising from the anterior circulation over a long-term follow-up period. METHODS We retrospectively reviewed our prospectively maintained database to identify all patients who underwent treatment for an intracranial saccular (unruptured or beyond the acute hemorrhage phase) aneurysm arising from the anterior circulation with ≥1 p64 between December 2011 and December 2019. Fusiform aneurysms and dissections were excluded. Aneurysms with prior or concomitant saccular treatment (eg, coiling and clipping) were included. Aneurysms with parent vessel implants other than p64 were excluded. Anatomic features, intraprocedural complications, clinical outcome, as well as clinical and angiographic follow-ups were all recorded. RESULTS In total, 530 patients (388 females; median age 55.9 yr) with 617 intracranial aneurysms met the inclusion criteria. The average number of devices used per aneurysm was 1.1 (range 1-3). Mean aneurysm dome size was 4.8 mm (range 1-27 mm). Treatment-related morbimortality was 2.4%. Early, mid-term, and long-term angiographic follow-up showed complete or near-complete aneurysm occlusion in 76.8%, 89.7%, and 94.5%, respectively. CONCLUSION Treatment of intracranial saccular unruptured aneurysms of the anterior circulation using p64 is a safe and effective treatment option with high rate of occlusion at long-term follow-up and low morbimortality. Graphical Abstract Graphical Abstract |
| Databáze: | OpenAIRE |
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