Fibroadenoma of the breast: Diagnostic pitfalls of fine-needle aspiration
| Autor: | R Kara, J. L. Benoit, Máire A. Duggan, S E McGregor |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Histology Mammary gland Breast Neoplasms Malignancy Pathology and Forensic Medicine Diagnosis Differential Biopsy Carcinoma medicine False positive paradox Humans False Positive Reactions skin and connective tissue diseases False Negative Reactions medicine.diagnostic_test business.industry Biopsy Needle General Medicine Middle Aged medicine.disease Fibroadenoma body regions medicine.anatomical_structure Fine-needle aspiration Female Adenofibroma business |
| Zdroj: | Diagnostic Cytopathology. 8:643-647 |
| ISSN: | 1097-0339 8755-1039 |
| DOI: | 10.1002/dc.2840080623 |
| Popis: | On fine-needle aspiration (FNA), fibroadenomas have a characteristic cytological appearance, although occasional cases are misinterpreted as carcinomas and vice versa. In a review of 521 breast aspirates correlated with the subsequent histology, six of 87 fibroadenomas (7%) were malignant or suspicious of malignancy on FNA (false positives). Following cytological review, four were still suspicious of malignancy because of cellular dyscohesion and prominent nucleoli, while two were fibroadenomas. On FNA, four of 145 carcinomas (3%) were diagnosed as fibroadenomas (false negatives). On review, three were malignant or suspicious of malignancy, while one was consistent with a fibroadenoma. Three false negative diagnoses were due to underappreciation of single malignant cells present between epithelial groupings typical of a fibroadenoma, while one was due to undersampling of the carcinoma. Cytologically, some fibroadenomas are sufficiently atypical that histological confirmation is necessary to exclude a malignancy. Misinterpreting carcinomas as fibroadenomas could be avoided by careful study of the morphology of isolated cells. |
| Databáze: | OpenAIRE |
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