Replacement of Metaphylactic Antimicrobial Therapy by Oral Administration of Ligilactobacillus salivarius MP100 in a Pig Farm
| Autor: | O. J. Sobrino, Juan M. Rodríguez, Antonio Fumanal, Rebeca Arroyo, Susana Delgado, Leónides Fernández, Claudio Alba, Lydia Sariego, Julián de María, Inés Pérez, Pilar Fumanal |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
antibiotic resistance
Swine Antibiotic resistance animal diseases Veterinary medicine Butyrate antimicrobials law.invention Clostridia 03 medical and health sciences Probiotic fluids and secretions Oral administration law SF600-1100 Food science Feces Original Research 030304 developmental biology 0303 health sciences General Veterinary biology 030306 microbiology Antimicrobials Probiotics food and beverages Short chain fatty acids swine Antimicrobial biology.organism_classification probiotics Ligilactobacillus salivarius Veterinary Science Microbiome short chain fatty acids Bacteria |
| Zdroj: | Frontiers in Veterinary Science, Vol 8 (2021) Digital.CSIC. Repositorio Institucional del CSIC instname Frontiers in Veterinary Science |
| ISSN: | 2297-1769 |
| DOI: | 10.3389/fvets.2021.666887/full |
| Popis: | Antibiotic use in swine production contributes to the emergence and spread of resistant bacteria, which poses a threat on human health. Therefore, alternative approaches must be developed. The objective of this work was the characterization of the probiotic properties of a Ligilactobacillus salivarius strain isolated from sow's milk and its application as an inoculated fermented feed to pregnant sows and piglets. The study was carried in a farm in which metaphylactic use of antimicrobials (including zinc oxide) was eliminated at the time of starting the probiotic intervention, which lasted for 2 years. Feces from 8-week-old piglets were collected before and after the treatment and microbiological and biochemical analyses were performed. The procedure led to an increase in the concentrations of clostridia and lactobacilli-related bacteria. Parallel, an increase in the concentration of butyrate, propionate and acetate was observed and a notable reduction in the presence of antibiotic resistant lactobacilli became apparent. In conclusion, replacement of antimicrobials by a microbiota-friendly approach was feasible and led to positive microbiological and biochemical changes in the enteric environment. |
| Databáze: | OpenAIRE |
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