Voltammetric studies of the effect of Cisplatin-liposome on Hela cells

Autor:	Sheng-wen Hu, Dieyan Chen, Min-zheng Zhao, Shan Wang, Wen-Bao Chang, Chunyang Zhang, Qi Zhai, Hui Ma, Yun-Xiang Ci
Rok vydání:	2001
Předmět:	Cisplatin Membrane potential Liposome biology Chemistry Analytical chemistry biology.organism_classification In vitro Analytical Chemistry HeLa Electron transfer Cisplatin liposome medicine Biophysics Voltammetry medicine.drug
Zdroj:	Talanta. 55:693-698
ISSN:	0039-9140
DOI:	10.1016/s0039-9140(01)00480-5
Popis:	In this paper, the voltammetric method was used for the first time to study the effect of Cisplatin-liposome on Hela cells. The results showed the voltammetric behavior of Hela cells was irreversible and the peak current had linear relationship with the cell number. With both Cisplatin-liposome concentration and treating time increasing, the peak current decreased. The peak current decreasing was in accordance with the nuclear damage and loss of mitochondrial membrane potential revealed by two-photon laser scanning microscopy and confocal laser scanning microscopy. This voltammetric method may provide a simple way to study the electron-transfer mechanism in drug-treating cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95b7e93181a257ea9402fb22c9a46a70 https://doi.org/10.1016/s0039-9140(01)00480-5 Zobrazit plný text záznamu Full Text from ScienceDirect