A comprehensive manually curated reaction map of RANKL/RANK-signaling pathway
| Autor: | Subburaman Mohan, Derese Getnet, Mohan R. Wani, Akhilesh Pandey, Vishalakshi Nanjappa, Joji Kurian Thomas, Lavanya Balakrishnan, Mitali Bhattacharjee, T. S. Keshava Prasad, Gary D. Bader, Subramanian Shankar, Babylakshmi Muthusamy, H. C. Harsha, Jyoti Sharma, B. Abdul Rahiman, Rajesh Raju |
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| Rok vydání: | 2011 |
| Předmět: |
musculoskeletal diseases
MAPK/ERK pathway Databases Factual Bioinformatics General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Osteoclast medicine Humans PI3K/AKT/mTOR pathway 030304 developmental biology 0303 health sciences Receptor Activator of Nuclear Factor-kappa B biology RANK Ligand NFAT Cell biology medicine.anatomical_structure RANKL 030220 oncology & carcinogenesis Mitogen-activated protein kinase biology.protein Database Management Systems Original Article Signal transduction General Agricultural and Biological Sciences Signal Transduction Information Systems |
| Zdroj: | Database: The Journal of Biological Databases and Curation |
| ISSN: | 1758-0463 |
| DOI: | 10.1093/database/bar021 |
| Popis: | Receptor activator of nuclear factor-kappa B ligand (RANKL) is a member of tumor necrosis factor (TNF) superfamily that plays a key role in the regulation of differentiation, activation and survival of osteoclasts and also in tumor cell migration and bone metastasis. Osteoclast activation induced by RANKL regulates hematopoietic stem cell mobilization as part of homeostasis and host defense mechanisms thereby linking regulation of hematopoiesis with bone remodeling. Binding of RANKL to its receptor, Receptor activator of nuclear factor-kappa B (RANK) activates molecules such as NF-kappa B, mitogen activated protein kinase (MAPK), nuclear factor of activated T cells (NFAT) and phosphatidyl 3-kinase (PI3K). Although the molecular and cellular roles of these molecules have been reported previously, a systematic cataloging of the molecular events induced by RANKL/RANK interaction has not been attempted. Here, we present a comprehensive reaction map of the RANKL/RANK-signaling pathway based on an extensive manual curation of the published literature. We hope that the curated RANKL/RANK-signaling pathway model would enable new biomedical discoveries, which can provide novel insights into disease processes and development of novel therapeutic interventions. Database URL: http://www.netpath.org/pathways?path_id=NetPath_21 |
| Databáze: | OpenAIRE |
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