Effects of trans-sobrerol on drug metabolizing enzymes in the rat
| Autor: | A. Lippi, F. Luzzani, P. G. Gervasi, Franco Marioni, P. Ventura, Giuseppe Bellucci |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Male
medicine.medical_specialty Health Toxicology and Mutagenesis Metabolite Glucuronates In Vitro Techniques Toxicology Biochemistry Mixed Function Oxygenases Lipid peroxidation chemistry.chemical_compound Species Specificity Internal medicine medicine Animals Lung Pharmacology biology Chemistry Terpenes Cytochrome P450 Rats Inbred Strains Stereoisomerism General Medicine Metabolism Glutathione Rats Enzyme Activation Cytosol Endocrinology Inactivation Metabolic Microsome biology.protein Microsomes Liver Sobrerol Electrophoresis Polyacrylamide Gel Indicators and Reagents Lipid Peroxidation Subcellular Fractions |
| Zdroj: | Xenobiotica; the fate of foreign compounds in biological systems. 19(8) |
| ISSN: | 0049-8254 |
| Popis: | 1. Metabolism of 14C-trans-sobrerol (I) by Sprague-Dawley rat liver microsomes did not result in covalent binding to proteins, lipid peroxidation or cytochrome P-450 destruction. 2. Subacute and chronic treatment of Sprague-Dawley rats with (I) resulted only in an increase in liver cytosolic GSH-S-transferase. 3. Acute treatment of rats with trans-sobrerol or its metabolite, 8-hydroxycarvotanacetone (II) produced considerable GSH depletion, faster in the case of II, in both liver and lung; the original GSH levels were restored within 24 h. No significant increase in lipid peroxidation was found even when GSH was at its lowest level. 4. UDP-glucuronyltransferase and GSH-S-transferase conjugation occurred with trans-sobrerol and some of its metabolites although at low rates. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|