Early Histopathological Changes in New-Onset Diabetes After Kidney Transplantation
| Autor: | C Lengyel, Csilla Keresztes, Bernadett Borda, György Lázár, A. Kubik, Y. Munir Ibrahim, Tamás Várkonyi |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Graft Rejection Male medicine.medical_specialty Biopsy medicine.medical_treatment Gastroenterology Tacrolimus Impaired glucose tolerance chemistry.chemical_compound Risk Factors Internal medicine Diabetes mellitus Diabetes Mellitus medicine Humans Transplantation Homologous Kidney transplantation Transplantation business.industry Immunosuppression Middle Aged medicine.disease Impaired fasting glucose Kidney Transplantation Early Diagnosis Endocrinology chemistry Uric acid Female Surgery business Immunosuppressive Agents |
| Zdroj: | Transplantation Proceedings. 46:2155-2159 |
| ISSN: | 0041-1345 |
| DOI: | 10.1016/j.transproceed.2014.05.057 |
| Popis: | Background New-onset diabetes after transplantation (NODAT) is one of the most common complications after kidney transplantation. Methods Patients were randomly assigned to receive cyclosporine A–based or tacrolimus-based immunosuppression. Fasting and oral glucose tolerance tests were performed, and the patients were assigned to one of the following 3 groups, on the basis of the results: normal, impaired fasting glucose/impaired glucose tolerance, or NODAT. NODAT developed in 14% of patients receiving cyclosporine A–based immunosuppression and in 26% of patients taking tacrolimus ( P = .0002). Results Albumin levels were similar, but uric acid level ( P = .002) and the age of the recipient ( P = .003) were significantly different between the diabetic and the normal groups. Evaluation of tissue samples revealed that acute cellular rejection and interstitial fibrosis/tubular atrophy were significantly different in the NODAT group. Changes in the Banff score provided significant difference regarding tubulitis and interstitial inflammation ( P = .05). Conclusions The pathological effect of new-onset diabetes after kidney transplantation can be detected in the morphology of the renal allograft earlier, before the development of any sign of functional impairment. |
| Databáze: | OpenAIRE |
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