Resting-state fMRI detects alterations in whole brain connectivity related to tumor biology in glioma patients
| Autor: | Marcus Unterrainer, Birgit Ertl-Wagner, Hesheng Liu, Sophia Stoecklein, Thomas Liebig, Jianxun Ren, Joerg-C. Tonn, Michael Schmutzer, Veit M Stoecklein, Franziska Galiè, Friedrich-W Kreth, Nathalie L. Albert, Niklas Thon |
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| Rok vydání: | 2020 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty IDH1 Neuroimaging Pathogenesis Glioma Humans Medicine Prospective Studies Prospective cohort study Biology medicine.diagnostic_test Resting state fMRI Brain Neoplasms business.industry Neuropsychology Brain Middle Aged medicine.disease Magnetic Resonance Imaging Oncology Neurology (clinical) Abnormality business Functional magnetic resonance imaging |
| Zdroj: | Neuro Oncol |
| ISSN: | 1523-5866 1522-8517 |
| DOI: | 10.1093/neuonc/noaa044 |
| Popis: | Background Systemic infiltration of the brain by tumor cells is a hallmark of glioma pathogenesis which may cause disturbances in functional connectivity. We hypothesized that aggressive high-grade tumors cause more damage to functional connectivity than low-grade tumors. Methods We designed an imaging tool based on resting-state functional (f)MRI to individually quantify abnormality of functional connectivity and tested it in a prospective cohort of patients with newly diagnosed glioma. Results Thirty-four patients were analyzed (World Health Organization [WHO] grade II, n = 13; grade III, n = 6; grade IV, n = 15; mean age, 48.7 y). Connectivity abnormality could be observed not only in the lesioned brain area but also in the contralateral hemisphere with a close correlation between connectivity abnormality and aggressiveness of the tumor as indicated by WHO grade. Isocitrate dehydrogenase 1 (IDH1) mutation status was also associated with abnormal connectivity, with more alterations in IDH1 wildtype tumors independent of tumor size. Finally, deficits in neuropsychological performance were correlated with connectivity abnormality. Conclusion Here, we suggested an individually applicable resting-state fMRI marker in glioma patients. Analysis of the functional connectome using this marker revealed that abnormalities of functional connectivity could be detected not only adjacent to the visible lesion but also in distant brain tissue, even in the contralesional hemisphere. These changes were associated with tumor biology and cognitive function. The ability of our novel method to capture tumor effects in nonlesional brain suggests a potential clinical value for both individualizing and monitoring glioma therapy. |
| Databáze: | OpenAIRE |
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