Varicella-Zoster Virus DNA in Cells Isolated from Human Trigeminal Ganglia
| Autor: | Lewis I. Pizer, Myron J. Levin, Michael D. Manchak, Guang-Yun Cai |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Herpesvirus 3 Human viruses Immunology Cell Herpes Zoster Polymerase Chain Reaction Microbiology Virus law.invention Trigeminal ganglion chemistry.chemical_compound law Virology Virus latency medicine Humans Polymerase chain reaction Aged Aged 80 and over Neurons integumentary system biology virus diseases biochemical phenomena metabolism and nutrition Middle Aged biology.organism_classification medicine.disease Virus Latency medicine.anatomical_structure Trigeminal Ganglion chemistry Insect Science DNA Viral Pathogenesis and Immunity Female Satellite (biology) Neuron DNA |
| Zdroj: | Journal of Virology. 77:6979-6987 |
| ISSN: | 1098-5514 0022-538X |
| Popis: | To determine the type of cell(s) that contain latent varicella-zoster virus (VZV) DNA, we prepared pure populations of neurons and satellite cells from trigeminal ganglia of 18 humans who had previously had a VZV infection. VZV DNA was present in 34 of 2,226 neurons (1.5%) and in none of 20,700 satellite cells. There was an average of 4.7 (range of 2 to 9) copies of VZV DNA per latently infected neuron. Latent VZV DNA was primarily present in large neurons, whereas the size distribution of herpes simplex virus DNA was markedly different. |
| Databáze: | OpenAIRE |
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