Requirement for Generation of H2O2for Platelet-Derived Growth Factor Signal Transduction
| Autor: | Victor J. Ferrans, Maitrayee Sundaresan, Zu Xi Yu, Kaikobad Irani, Toren Finkel |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Platelet-derived growth factor
Vascular smooth muscle medicine.medical_treatment Muscle Smooth Vascular Adenoviridae Cell Line chemistry.chemical_compound medicine Animals Humans Phosphorylation Phosphotyrosine Cells Cultured Mitogen-Activated Protein Kinase 1 Platelet-Derived Growth Factor Mitogen-Activated Protein Kinase 3 Multidisciplinary biology Chemotaxis Growth factor Serine Endopeptidases Tyrosine phosphorylation Free Radical Scavengers Hydrogen Peroxide Protein-Tyrosine Kinases Catalase Acetylcysteine Rats Cell biology chemistry Biochemistry Calcium-Calmodulin-Dependent Protein Kinases biology.protein Endopeptidase K Mitogen-Activated Protein Kinases Signal transduction Platelet-derived growth factor receptor Intracellular Signal Transduction |
| Zdroj: | Science. 270:296-299 |
| ISSN: | 1095-9203 0036-8075 |
| Popis: | Stimulation of rat vascular smooth muscle cells (VSMCs) by platelet-derived growth factor (PDGF) transiently increased the intracellular concentration of hydrogen peroxide (H2O2). This increase could be blunted by increasing the intracellular concentration of the scavenging enzyme catalase or by the chemical antioxidant N-acetylcysteine. The response of VSMCs to PDGF, which includes tyrosine phosphorylation, mitogen-activated protein kinase stimulation, DNA synthesis, and chemotaxis, was inhibited when the growth factor-stimulated rise in H2O2 concentration was blocked. These results suggest that H2O2 may act as a signal-transducing molecule, and they suggest a potential mechanism for the cardioprotective effects of antioxidants. |
| Databáze: | OpenAIRE |
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