The association between diabetes and gastric cancer: results from the Stomach Cancer Pooling Project Consortium
| Autor: | Gerson Shigeaki Hamada, Joshua E. Muscat, M. Constanza Camargo, Claudio Pelucchi, Rossella Bonzi, Robert C. Kurtz, Nuno Lunet, Stefania Boccia, Hung N. Luu, Chi Thi-Du Tran, Maria Paula Curado, Yen Thi-Hai Pham, Nerea Fernández de Larrea, Areti Lagiou, Paola Bertuccio, Guo-Pei Yu, Zuo-Feng Zhang, Eva Negri, Manolis Kogevinas, Domenico Palli, Monica Ferraroni, Matteo Rota, Jesús Vioque, Dmitry Maximovitch, Shoichiro Tsugane, Pagona Lagiou, David Zaridze, Anh Gia Pham, Akihisa Hidaka, Carlo La Vecchia, Roberta Pastorino, Bashir Dabo, Tin Nguyen, Harshonnati Jain, Aurora Sanchez-Anguiano, Paolo Boffetta |
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| Přispěvatelé: | Dabo, Bashir, Pelucchi, Claudio, Rota, Matteo, Jain, Harshonnati, Bertuccio, Paola, Bonzi, Rossella, Palli, Domenico, Ferraroni, Monica, Zhang, Zuo-Feng, Sanchez-Anguiano, Aurora, Thi-Hai Pham, Yen, Thi-Du Tran, Chi, Gia Pham, Anh, Yu, Guo-Pei, Nguyen, Tin C, Muscat, Joshua, Tsugane, Shoichiro, Hidaka, Akihisa, Hamada, Gerson S, Zaridze, David, Maximovitch, Dmitry, Kogevinas, Manoli, Fernàndez de Larrea, Nerea, Boccia, Stefania, Pastorino, Roberta, Kurtz, Robert C, Lagiou, Areti, Lagiou, Pagona, Vioque, Jesu, Camargo, M Constanza, Paula Curado, Maria, Lunet, Nuno, Boffetta, Paolo, Negri, Eva, La Vecchia, Carlo, Luu, Hung N, Italian Association for Cancer Research, Fondazione Italiana per la Ricerca sul Cancro, Italian League for the Fight Against Cancer, European Cancer Prevention, University of Pittsburgh Medical Center (Estados Unidos), Start-up |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Cancer Research
medicine.medical_specialty Epidemiology Oncology and Carcinogenesis Subgroup analysis Type 2 diabetes Helicobacter Infections diabetes gastric cancer risk factors Case-Control Studies Humans Risk Factors Diabetes Mellitus Type 2 Helicobacter pylori Stomach Neoplasms Clinical Research Diabetes mellitus Internal medicine medicine Diabetes Mellitus cancer Oncology & Carcinogenesis Stomach cancer Metabolic and endocrine Cancer business.industry Prevention Diabetes Public Health Environmental and Occupational Health Odds ratio medicine.disease Confidence interval Emerging Infectious Diseases Infectious Diseases Oncology Risk factors Public Health and Health Services business Serostatus Digestive Diseases Gastric cancer Type 2 |
| Zdroj: | EUROPEAN JOURNAL OF CANCER PREVENTION r-FISABIO. Repositorio Institucional de Producción Científica instname Repisalud Instituto de Salud Carlos III (ISCIII) European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), vol 31, iss 3 r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante r-FISABIO: Repositorio Institucional de Producción Científica Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
| ISSN: | 0959-8278 |
| Popis: | Background: Prior epidemiologic studies on the association between diabetes and gastric cancer risk provided inconclusive findings, while traditional, aggregate data meta-analyses were characterized by high between-study heterogeneity. Objective: To investigate the association between type 2 diabetes and gastric cancer using data from the ‘Stomach Cancer Pooling (StoP) Project’, an international consortium of more than 30 case–control and nested case–control studies, which is large and provides harmonized definition of participants’ characteristics across individual studies. The data have the potential to minimize between-study heterogeneity and provide greater statistical power for subgroup analysis. Methods: We included 5592 gastric cancer cases and 12 477 controls from 14 studies from Europe, Asia, North America, and South America in a two-stage individual-participant data meta-analysis. Random-effect models were used to estimate summary odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) by pooling study-specific ORs. Results: We did not find an overall association between diabetes and gastric cancer (pooled OR = 1.01, 95% CI, 0.94–1.07). However, the risk of cardia gastric cancer was significantly higher among individuals with type 2 diabetes (OR = 1.16, 95% CI, 1.02–1.33). There was no association between diabetes and gastric cancer risk in strata of Helicobacter pylori infection serostatus, age, sex, BMI, smoking status, alcohol consumption, fruit/vegetable intake, gastric cancer histologic type, and source of controls. Conclusion: This study provides additional evidence that diabetes is unrelated to gastric cancer overall but may be associated with excess cardia gastric cancer risk. This work was supported by Associazione Italiana per la Ricerca sul Cancro (AIRC), Project no. 21378 (Investigator Grant); Fondazione Italiana per la Ricerca sul Cancro (FIRC); Italian League for the Fight Against Cancer (LILT); European Cancer Prevention (ECP) Organization; and University of Pittsburgh Medical Center (UPMC) Start-up Grant (to H.N.L.). Sí |
| Databáze: | OpenAIRE |
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