Double-blind trial of solid lipid Boswellia serrata particles (SLBSP) vs. standardized Boswellia serrata gum extract (BSE) for osteoarthritis of knee
| Autor: | Vaidhun H. Bhaskar, Minal R. Ghante, Neena D Damle, Sumer Singh, Krishnat S Yadav, Lal Hingorani, Vikram S Gota, Preeti D Kulkarni |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Boswellia serrata extract WOMAC 030106 microbiology Anti-Inflammatory Agents Pain Urine Osteoarthritis Placebo 030226 pharmacology & pharmacy Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine Double-Blind Method Internal medicine medicine Humans Pharmacology (medical) Boswellia Prospective Studies Aged Aged 80 and over biology business.industry Plant Extracts Middle Aged Osteoarthritis Knee biology.organism_classification medicine.disease Clinical trial Boswellia serrata Cytokines Female business Tablets |
| Zdroj: | Drug metabolism and personalized therapy. 35(2) |
| ISSN: | 2363-8915 |
| Popis: | Objectives The present study was planned to investigate the efficacy of SLBSP vs. standardized BSE for symptomatic knee osteoarthritis (OA) treatment. Methods It was a prospective, randomized, double-blind, double-dummy, placebo-controlled, and single-centre clinical trial for symptomatic osteoarthritis of knee. Subjects were randomized to receive SLBSP capsule+BSE Placebo or BSE tablet+SLBSP placebo for two months. Patients were allowed to take rescue analgesics (Acelofenac 100 mg). Improvement in pain and function was assessed utilizing WOMAC, VAS. Level of CTX-II in urine and serum levels of inflammatory cytokines including IL-2, IL-4, IL-6, TNF-α, and IFN-γ was measured initially and at end of treatment. Results and conclusions Western Ontario and McMaster Universities osteoarthritis index (WOMAC) and Visual Analog Scale score improved markedly in SLBSP as well as in BSE arm (p |
| Databáze: | OpenAIRE |
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