Pharmacokinetics of murine p75-Fc fusion protein and MP6-XT22 anti-murine TNF-alpha mAb in mice
| Autor: | Scott G. Filler, Norma V. Solis, Jane Guo, Ana Ruiz-Garcia, George Doellgast, Wei-Jian Pan |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
musculoskeletal diseases
Male Necrosis medicine.drug_class Recombinant Fusion Proteins Dermatology Pharmacology Monoclonal antibody Receptors Tumor Necrosis Factor Etanercept Mice Pharmacokinetics medicine Animals Humans Molecular Biology Mice Inbred BALB C biology business.industry Tumor Necrosis Factor-alpha Candidiasis Antibodies Monoclonal Cell Biology General Medicine Fusion protein Infliximab Rats Immunoglobulin G biology.protein Tumor necrosis factor alpha medicine.symptom Antibody business Biotechnology medicine.drug |
| Zdroj: | The journal of investigative dermatology. Symposium proceedings. 12(1) |
| ISSN: | 1087-0024 |
| Popis: | Immunologic limitations make it difficult to study the pharmacokinetic effects of human tumor necrosis factor (TNF) blockers in murine models. To counter this, we have studied the pharmacokinetics in mice of two murine analogs of human TNF blockers, a murine p75-FC fusion protein (analogous to etanercept), and the rat MP6-XT22 anti-murine TNF mAb (analogous to infliximab). We analyzed the pharmacokinetics of the murine p75-Fc protein and MP6-XT22 antibody in mice that were uninfected and in mice with disseminated candidiasis in order to confirm dosing strategies and interpret future studies evaluating the efficacy and tolerability of these agents in mice. We propose that, while conducting safety or efficacy studies in murine disease models, it is reasonable to administer the murine p75-Fc protein to mice at10 mg/kg every 4-5 days, and the MP6-XT22 antibody at 10-20 mg/kg every 4-5 days. |
| Databáze: | OpenAIRE |
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