Prescribing Trend of Antirheumatic Drugs in Taiwan and Risk of Cardiovascular Disease in Patients with Rheumatoid Arthritis: A Nationwide Cohort Study

Autor:	Chien‑Ying Lee, Ya Fang Tsai, Kuang Hua Huang, Yu-Hsiang Kuan, Chih Jaan Tai, Chiu Hsiang Lee
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	Adult Male medicine.medical_specialty Databases Factual Article Subject Taiwan lcsh:Medicine Arthritis Drug Prescriptions General Biochemistry Genetics and Molecular Biology Arthritis Rheumatoid 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Diabetes mellitus medicine Humans 030212 general & internal medicine Risk factor Aged 030203 arthritis & rheumatology General Immunology and Microbiology business.industry lcsh:R Hazard ratio Retrospective cohort study General Medicine Middle Aged medicine.disease Cardiovascular Diseases Antirheumatic Agents Rheumatoid arthritis Female business Research Article Kidney disease Cohort study
Zdroj:	BioMed Research International BioMed Research International, Vol 2019 (2019)
ISSN:	2314-6133
DOI:	10.1155/2019/7987529
Popis:	We aimed to investigate the prescribing trend of antirheumatic drugs and assess the risk of cardiovascular disease in patients with rheumatoid arthritis in Taiwan. This study was a retrospective cohort study, conducted based on the Taiwan National Health Insurance Research Database. The study subjects were 15,366 new rheumatoid arthritis patients from 2003 to 2010. To avoid selection bias, we applied propensity score matching to obtain general patients, as the control group. Cox proportional hazard model was used to evaluate the risk of cardiovascular disease in rheumatoid arthritis patients. The most common prescriptions of rheumatoid arthritis were nonsteroidal anti-inflammatory drugs. After controlling for related variables, rheumatoid arthritis patients had a higher risk of cardiovascular disease than general patients (adjusted hazard ratio [aHR] = 1.31; 95% confidence interval [CI]: 1.23-1.39). Age was the most significantly associated risk factor with the cardiovascular disease. Other observed risk factors for cardiovascular disease included hypertension (aHR = 1.57, 95% CI: 1.48-1.65), diabetes mellitus (aHR = 1.47, 95% CI: 1.38-1.57), and chronic kidney disease (aHR = 1.48, 95% CI: 1.31-1.66). Patients with rheumatoid arthritis indeed had a higher risk of incident cardiovascular diseases. Besides, age, hypertension, diabetes mellitus, and chronic kidney disease were also associated with a higher risk of cardiovascular disease.
Databáze:	OpenAIRE
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