Body composition, bone mineral density and fractures in late postmenopausal women with polycystic ovary syndrome - a long-term follow-up study
| Autor: | Eva Dahlgren, Mats Brännström, Johanna Schmidt, Kerstin Landin-Wilhelmsen |
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| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Fractures Bone Endocrinology Sex hormone-binding globulin Bone Density Internal medicine medicine Humans Osteoporosis Postmenopausal Aged Aged 80 and over Bone mineral biology Free androgen index business.industry Incidence (epidemiology) Hyperandrogenism Middle Aged Anthropometry medicine.disease Polycystic ovary Postmenopause Body Composition biology.protein Lean body mass Female business Follow-Up Studies Polycystic Ovary Syndrome |
| Zdroj: | Clinical Endocrinology. 77:207-214 |
| ISSN: | 0300-0664 |
| DOI: | 10.1111/j.1365-2265.2012.04378.x |
| Popis: | SummaryObjective Hyperandrogenism is one of the characteristic features of the polycystic ovary syndrome (PCOS). Androgens are important for bone mass. Studies on bone mineral density (BMD) and fractures in postmenopausal women with PCOS are lacking. The aim of this study was to investigate whether postmenopausal women with PCOS differ from controls regarding body composition, BMD and prevalence of fractures, and to compare women with PCOS with controls regarding correlations between total BMD and sex hormones. Design A prospective 21-year follow-up study. Anthropometry, hormonal measurements and questionnaires were performed in 1987 and in 2008. Fractures were X-ray-verified. BMD measurements were taken in 1992, using single-photon absorptiometry (SPA), and in 2008, using dual-energy X-ray absorptiometry (DXA), to also enable measurements of body composition. Patients Twenty-five women with PCOS (Rotterdam criteria), aged 61–78 years, and 68 randomly allocated age-matched controls. Measurements Body composition, BMD, fractures and sex steroids. Results At follow-up, the postmenopausal women with PCOS maintained a higher free androgen index (FAI), but had similar body fat, lean mass and BMD compared with controls. The hip circumference increased only in women with PCOS (P |
| Databáze: | OpenAIRE |
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