Depth-resolved blood oxygen saturation measurement by dual-wavelength photothermal (DWP) optical coherence tomography

Autor: Jeffrey W. Kiel, Thomas E. Milner, Austin McElroy, Roman V. Kuranov, Jinze Qiu, Arnold D. Estrada, Anthony Salvaggio, Timothy Q. Duong, Andrew K. Dunn
Rok vydání: 2010
Předmět:
Pathology
medicine.medical_specialty
Materials science
genetic structures
Forward scatter
Noninvasive Optical Diagnostics
01 natural sciences
Light scattering
Imaging phantom
010309 optics
03 medical and health sciences
Optical coherence tomography
0103 physical sciences
medicine
030304 developmental biology
0303 health sciences
ocis:(300.1030) Absorption
medicine.diagnostic_test
musculoskeletal
neural
and ocular physiology
ocis:(120.5050) Phase measurement
(170.6510) Spectroscopy
tissue diagnostics
Photothermal therapy
Atomic and Molecular Physics
and Optics
respiratory tract diseases
Wavelength
Oxygen Saturation Measurement
ocis:(170.1470) Blood or tissue constituent monitoring
Attenuation coefficient
sense organs
ocis:(170.4500) Optical Coherence Tomography
Biotechnology
Biomedical engineering
circulatory and respiratory physiology
Zdroj: Biomedical Optics Express
ISSN: 2156-7085
Popis: Non-invasive depth-resolved measurement of hemoglobin oxygen saturation (SaO(2)) levels in discrete blood vessels may have implications for diagnosis and treatment of various pathologies. We introduce a novel Dual-Wavelength Photothermal (DWP) Optical Coherence Tomography (OCT) for non-invasive depth-resolved measurement of SaO(2) levels in a blood vessel phantom. DWP OCT SaO(2) is linearly correlated with blood-gas SaO(2) measurements. We demonstrate 6.3% precision in SaO(2) levels measured a phantom blood vessel using DWP-OCT with 800 and 765 nm excitation wavelengths. Sources of uncertainty in SaO(2) levels measured with DWP-OCT are identified and characterized.
Databáze: OpenAIRE
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